Phase 1 Study of Phototherapy System to Treat H Pylori

Inclusion Criteria:

- Age > 18 and < 90

- Documented positive for H. pylori infection by urease breath test, stool antigen or
histology within thirty days prior to procedure

- Willing to comply with study requirements

- Able to undergo endoscopic esophagogastroduodenoscopy (EGD) with biopsy

Exclusion Criteria:

- History of gastric or duodenal carcinoma

- History of prior gastric or duodenal surgery

- Oral or intravenous antibiotics use within previous one month

- Use of bismuth subsalicylate (Pepto Bismol) within previous one month

- Use of photosensitizing drugs or nutritional supplements within previous one month

- Active peptic ulcer disease (gastric or duodenal ulcer)

- Esophagitis Grade II or higher

- Oral or intravenous antibiotics use within previous one month

- History of a bleeding disorder or anti-coagulant use that would prevent biopsy

- PPI treatment two weeks prior to the scheduled endoscopy

- Positive Pregnancy Test

- Known porphyria

- Suffer from phenylketonuria (PKU)

- Signs of jaundice

- Weight < 100 lb or > 250 lb

- Previously enrolled in this study

- Participating in another ongoing clinical trial in which concomitant diagnosis or
therapeutic intervention would adversely affect the integrity of this study

- The subject is inappropriate for study participation, as determined by the
Investigator