An Exploratory Clinical Trial of Zoledronic Acid in Women With CIN 2/3 or 3

Inclusion Criteria

DISEASE CHARACTERISTICS:

- Biopsy confirmed cervical intraepithelial neoplasia (CIN) 2/3 or 3

- Planning loop excision or cone biopsy

- Diagnosis within 2 months prior to study entry

- Standard histological grading according to Richart

- Visible lesion by colposcopy

- No unsatisfactory colposcopy or lesions extending into the endocervical canal
that cannot be visualized entirely by colposcopy

- No suspicion of invasive cervical cancer by cytology, histology or colposcopy

- No cytologic evidence of glandular atypia or dysplasia

PATIENT CHARACTERISTICS:

- Creatinine normal

- Screening laboratory values within normal range (e.g., complete blood count, liver
function tests, renal panel, and electrolytes)

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- Able to read and speak English or Spanish

- No known hypersensitivity to bisphosphonates

- Not immunocompromised

- No known HIV positivity

- No aspirin-sensitive asthma due to association of bisphosphonates with
bronchoconstriction

- No unexplained abnormal vaginal bleeding

PRIOR CONCURRENT THERAPY:

- No concurrent loop diuretics, aminoglycosides, other nephrotoxic drugs,
immunosuppressive drugs, or other investigational agents