Inclusion Criteria:

1. Men >18 years of age. No upper age limit

2. Written informed consent approved by institutional review board should be explained
to and signed by patient

3. Documentation of histologically confirmed adenocarcinoma of the prostate. Gleason
score of any sum is allowed on this study.

4. Metastatic disease as evidenced by visceral involvement, bone disease, or PSA
elevation.

5. Patients should meet the criteria of androgen independent prostate cancer (AIPC).
Patients would fulfill these criteria if they continue to progress despite complete
androgen blockade (surgical or medical castration with anti-androgen) and despite an
anti-androgen withdrawal trial. Failing anti-androgen withdrawal is defined as no
decline by 25% or more 3-weeks after stopping anti-androgens.

Progression on hormonal therapy is defined as ANY of the following:

- PSA: 2 consecutive rising PSA values, at least 14-days apart, each being > 5
ng/ml

- For patients with visceral measurable disease, progression is defined as an
increase by 50% or more in the size of measurable areas, or any development of
new lesions.

- For patients with bone-only disease, progression is defined as the appearance of
2 or more new areas of abnormal uptake on a bone scan, when compared to prior
imaging studies. Changes in the uptake of already existing lesions will NOT be
used to define progressive disease.

- For patients with bone AND visceral disease, fulfilling any of the criteria in
5.2 or 5.3 is sufficient to define progression.

6. Castration levels of testosterone (< 50 ng/dl) achieved via medical or surgical
castration. Patients should continue on LHRH agonists throughout if this is the
method used to achieve castration.

7. Life expectancy of at least 6 months

8. Adequate hematologic, renal, and liver function as evidenced by the following:

- WBC > 2000,

- ANC > 1000,

- Platelet count > 100,000,

- HgB > 9.0 g/dl, Creatinine < 2,

- Total bilirubin < 2x upper limit of normal,

- AST and ALT < 3 x upper limit of normal

9. ECOG performance status of 0 or 1.

10. The use of intravenous polyphosphates for bone metastases is allowed.

11. upon completion of the taxotere portion of study, patient can be enrolled & receive
GM-CSF if ANY of the following criteria is met:

- Patients received total of 8 cycles of taxotere & have no signs of disease
progression

- Patients achieved their maximal response despite receiving < than 8 cycles of
taxotere. Maximum response is defined as a drop in measures of PSA by 10% or
less on 2 consecutive measurements.

- Patients who have completed their chemotherapy < than 12 weeks prior to opening
this trial & still have stable disease without progression (by PSA and
radiographically) will be eligible to receive maintenance GM-CSF

Exclusion Criteria:

1. presence of brain metastases

2. Known HIV+ status

3. ECOG performance status of 2 or higher

4. Use of investigational agents within 4 weeks of starting

5. Patients with prior exposure to more than one chemotherapy program Patients who have
received one chemotherapy schedule can be enrolled on study and receive GM-CSF (the
maintenance arm) if their last chemotherapy was taxotere, given within the past 12
weeks, and they have demonstrated NO evidence of progression radiographically and
biochemically. Prior exposure to steroids is NOT an exclusion criteria.

6. Patients with other active malignancies (excluding non-melanoma skin cancers)are
excluded. Prior malignancies are not exclusion criteria as long as last treatment for
such malignancies was over 5 years prior to enrollment.

7. Treatment with investigational products are NOT an exclusion criteria, if therapy was
last received over 4 weeks prior to enrollment.

8. Any medical intervention or other condition which, in the opinion of the principle
investigator, could compromise adherence with study requirements.