Phase I Examination of Combination High Dose-Rate Brachytherapy and/or Intensity Modulated External Beam Therapy for the Comprehensive Local Treatment of Patients With Locally Confined Adenocarcinoma of the Prostate

Inclusion Criteria:

- TRUS biopsy proven adenocarcinoma of the prostate Pretreatment PSA <30 ng/ml
Gleason's sum < 8 clinical stage T1 or T2a,b. patients that are at low-intermediate
risk for disease beyond the prostate normal liver function for all patients beginning
hormone therapy Karnofsky Performance score > 80 acceptable anesthesia risk as
determined through routine pre-operative screening in the VCUHS Diagnostic Testing
Clinic

Exclusion Criteria:

- pubic-arch interference or regional disease ( no evidence of metastatic disease for
patients whose PSA is greater than 10 ng/ml, Gleason's sum is greater than 6, or
T-stage is greater than T2a.

Patients at high risk for distant disease (PSA > 30 ng/ml, Gleason's sum > 8 or clinical
stage > T2c), clinically involved seminal vesicles or extension beyond the prostate
capsule history of inflammatory bowel disease require steroid or cytotoxic therapy for
collagen vascular disease uncontrolled or poorly controlled hypertension uncontrolled or
poorly controlled diabetes mellitus history of cancer other than skin cancer within five
years of the initiation of protocol treatment history of pelvic irradiation require the
routine use of warfarin