Inclusion Criteria:

- Able to comprehend and sign an IRB approved Informed consent

- Willingness and ability to comply with the FDA-mandated S.T.E.P.S.® program.

- Male or female 18 years or older

- Willing to use contraception

- Pathologic diagnosis of renal cell carcinoma

- Bi-dimensionally measurable disease

- Evidence of disease progression prior to start of treatment

- Failed prior immunotherapy or unwilling/unable to receive prior immunotherapy

- Adequate hematologic data: ANC.1.5; platelets>100x10^9

- Adequate renal function: Creatinine clearance .50cc

- Adequate liver function: Alkaline phos <3XULN AST/ALT <3XULN T.Bili <1.5XULN

- ECOG performance status 0-1

Exclusion Criteria:- Known brain metastases.

- Peripheral neuropathy.

- Pregnant and/ or lactating female.

- Unable to take a baby aspirin.