Rituximab +/- Bevacizumab in the Treatment of Patients With Follicular Non-Hodgkin's Lymphoma: A Randomized, Phase II Trial
Upon determination of eligibility, patients will randomly be assigned to one of two
treatment arms:
- Rituximab
- Rituximab + bevacizumab
For every 2 patients randomized, 1 will receive treatment number 1 (rituximab), and 1
patient will receive treatment number 2 (rituximab + bevacizumab). This is not a blinded
study, so both the patient and doctor will know which treatment has been assigned.
Interventional
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Overall Response Rate (ORR), the Percentage of Patients Who Experience an Objective Benefit From Treatment
Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0) for target lesions and assessed by MRI or CT: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR.
18 months
No
John D Hainsworth, MD
Principal Investigator
Sarah Cannon Research Institute
United States: Food and Drug Administration
SCRI LYM 37
NCT00193492
September 2005
December 2013
Name | Location |
---|---|
Florida Hospital Cancer Institute | Orlando, Florida 32804 |
Northeast Arkansas Clinic | Jonesboro, Arkansas 72401-3125 |
Florida Cancer Specialists | Fort Myers, Florida 33901 |
Northeast Georgia Medical Center | Gainesville, Georgia 30501 |
Spartanburg Regional Medical Center | Spartanburg, South Carolina 29303 |
Integrated Community Oncology Network | Jacksonville Beach, Florida 32250 |
Methodist Cancer Center | Omaha, Nebraska 68114 |
Medical Oncology Associates of Augusta | Augusta, Georgia 30901 |
Center for Cancer and Blood Disorders | Bethesda, Maryland 20817 |
Tennessee Oncology, PLLC | Clarksville, Tennessee 37043 |
Wellstar Cancer Research | Marietta, Georgia 30060 |
Oncology Hematology Care | Cincinnati, Ohio 45242 |
Graves-Gilbert Clinic | Bowling Green, Kentucky 42101 |
Watson Clinic for Cancer Research | Lakeland, Florida 33805 |
Providence Medical Group | Terre Haute, Indiana 47802 |
Baptist Hospital East | Louisville, Kentucky 40207 |
Norton Cancer Institute | Louisville, Kentucky 40207 |
Hematology Oncology Clinic, LLP | Baton Rouge, Louisiana 70809 |
National Capital Clinical Research Consortium | Bethesda, Maryland 20817 |
Hematology Oncology Associates of Northern NJ | Morristown, New Jersey 07960 |
Berks Hematology Oncology Associates | West Reading, Pennsylvania 19611 |
Chattanooga Oncology Hematology Associates | Chattanooga, Tennessee 37404 |