Inclusion Criteria:

- Patients with histologically or cytologically confirmed advanced or metastatic
gastric or gastroesophageal cancer. Histology must be consistent with
adenocarcinoma.

- No previous chemotherapy for metastatic or unresectable disease. Prior adjuvant
therapy is allowed, as long as it was completed within six months of study
initiation.

- Ability to understand and willingness to sign a written informed consent prior to
study-specific screening procedures, with the understanding that the patient has the
right to withdraw from the study at any time, without prejudice.

- SWOG performance status of less than or equal to 2.

- At least one measurable lesion, according to the Response Evaluation Criteria in
Solid Tumors (RECIST) criteria, which has not been irradiated (i.e. newly arising
lesions in previously irradiated areas are accepted). Ascites, pleural effusion, and
bone metastases are not considered measurable. Minimum indicator lesion size: > 10
mm measured by spiral computed tomography (CT) or > 20 mm measured by conventional
techniques.

- Have a negative serum or urine pregnancy test within 7 days prior to initiation of
chemotherapy (female patients of childbearing potential).

- Availability of tumor biopsy (paraffin embedded or fresh frozen) at the time of
diagnosis and/or prior to study entry is required.

- Patients must agree to use an effective form of birth control while on study and to
continue this contraceptive method for 30 days from the date of the last study drug
administration.

Exclusion Criteria:

- Pregnant or lactating women.

- Life expectancy of < 3 months.

- Serious, uncontrolled, concurrent infection(s) or illness(es).

- Any prior oxaliplatin treatment.

- Prior unanticipated severe reaction to fluoropyrimidine therapy, known
hypersensitivity to 5-fluorouracil or known DPD deficiency.

- Prior unanticipated severe reaction or hypersensitivity to platinum based compounds.

- Completion of previous chemotherapy regimen < four weeks prior to the start of study
treatment (within six weeks of study treatment for mitomycin C and nitroureas), or
with related toxicities unresolved prior to the start of study treatment.

- Treatment for other carcinomas within the last five years, except for cured
non-melanoma skin cancer and treated in-situ cervical cancer.

- Participation in any investigational drug study within 4 weeks preceding the start of
study treatment.

- Clinically significant cardiac disease (e.g. congestive heart failure, symptomatic
coronary artery disease and cardiac arrhythmias not well controlled with medication)
or myocardial infarction within the last 12 months.

- History of clinically significant interstitial lung disease and/or pulmonary
fibrosis.

- History of persistent neurosensory disorder including but not limited to peripheral
neuropathy

- Evidence of central nervous system (CNS) metastases (unless CNS metastases have been
stable for > 3 months) or history of uncontrolled seizures, central nervous system
disorders or psychiatric disability judged by the investigator to be clinically
significant, precluding informed consent, or interfering with compliance of oral drug
intake. Other serious uncontrolled medical conditions that the investigator feels
might compromise study participation.

- Major surgery within 4 weeks of the start of study treatment, without complete
recovery.

- Lack of physical integrity of the upper gastrointestinal tract or malabsorption
syndrome.

- Any of the following laboratory values:

- Abnormal hematologic values (neutrophils < 1.5 x 10^9/L, platelet count < 100 x
109/L)

- Impaired renal function (estimated creatinine clearance < 30 ml/min as
calculated with Cockroft-Gault equation and serum creatinine > 1.5 x upper
normal limit).

- Serum bilirubin > 1.5 x upper normal limit.

- ALT, AST > 2.5 x upper normal limit (or > 5 x upper normal limit in the case of
liver metastases).

- Alkaline phosphatase > 2.5 x upper normal limit (or > 5 x upper normal limit in
the case of liver metastases or > 10 x upper normal limit in the case of bone
disease).

- Unwillingness to participate or inability to comply with the protocol for the
duration of the study.

- Known, existing uncontrolled coagulopathy

- Prior therapy which specifically and directly targets the EGFR pathway.

- Prior severe infusion reaction to a monoclonal antibody