A Pilot Study of Irradiated HLA-Partially Matched Allogeneic Related Donor Lymphocytes for Patients With Selected Malignancies

Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically confirmed diagnosis of 1 of the following:

- Hematologic cancer, including any of the following:

- Chronic lymphocytic leukemia or small lymphocytic lymphoma meeting any of
the following criteria:

- Relapsed within 1 year after prior fludarabine phosphate-containing
regimens OR not a candidate to receive such therapy due to
comorbidities or allergies

- Received prior anti-CD52 monoclonal antibody therapy OR ineligible to
receive such therapy (for patients without symptomatic
lymphadenopathy)

- Has documentation of disease-associated symptoms, rapid progression of
disease, or other indications for treatment

- B- or T-cell prolymphocytic leukemia meeting any of the following criteria:

- Relapsed within 1 year after prior fludarabine phosphate- or
alkylating agent-containing regimens OR not a candidate to receive
such therapy due to comorbidities or allergies

- Relapsed within 1 year after prior anti-CD20 monoclonal antibody
therapy OR ineligible to receive such therapy (for patients with
CD20-positive disease)

- Received prior anti-CD52 monoclonal antibody therapy OR ineligible to
receive such therapy (for patients without symptomatic
lymphadenopathy)

- Lymphoplasmacytic lymphoma, marginal zone lymphoma, mucosa-associated
lymphoid tissue lymphoma, or follicular lymphoma meeting any of the
following criteria:

- Relapsed within 1 year after prior fludarabine phosphate- or
alkylating agent-containing regimens or radioconjugated anti-CD20
monoclonal antibody OR not a candidate to receive such therapy due to
comorbidities or allergies

- Relapsed within 1 year after prior anti-CD20 monoclonal antibody
therapy OR ineligible to receive such therapy (for patients with
CD20-positive disease)

- Has documentation of disease-associated symptoms, rapid progression of
disease, or other indications for treatment

- Multiple myeloma meeting any of the following criteria:

- Relapsed after prior alkylating agents, thalidomide, corticosteroids,
or bortezomib OR not a candidate to receive such therapy due to
comorbidities or allergies

- Relapsed after prior high-dose chemotherapy followed by autologous
hematopoietic stem cell rescue OR not a candidate to receive such
therapy

- Mantle cell lymphoma that has relapsed after prior combination chemotherapy
or anti-CD20 monoclonal antibody OR not a candidate to receive such therapy

- Diffuse large B-cell lymphoma meeting any of the following criteria:

- Relapsed after prior salvage combination chemotherapy with or without
high-dose chemotherapy followed by autologous hematopoietic stem cell
rescue OR not a candidate to receive such therapy

- Received prior radiolabeled anti-CD20 monoclonal antibody OR
ineligible to receive such therapy (for patients with transformed
large cell lymphoma)

- Burkitt's lymphoma

- Relapsed after prior salvage combination chemotherapy with or without
high-dose chemotherapy followed by autologous hematopoietic stem cell
rescue OR not a candidate for such therapy

- Lymphomatoid granulomatosis or mature T-cell or NK-cell neoplasms meeting
any of the following criteria:

- Relapsed after prior single agent or combination chemotherapy OR not a
candidate to receive such therapy

- Has documentation of disease-associated symptoms, rapid progression of
disease, or other indications for treatment

- Mycosis fungoides or Sezary syndrome

- Relapsed after prior combination chemotherapy, interferon-α,
denileukin diftitox, or extracorporeal photophoresis OR not a
candidate to receive such therapy

- Anaplastic large cell lymphoma, peripheral T-cell lymphoma unspecified, or
angioimmunoblastic T-cell lymphoma meeting the following criteria:

- Relapsed after prior salvage combination chemotherapy with or without
high-dose chemotherapy followed by autologous hematopoietic stem cell
rescue OR not a candidate to receive such therapy

- Hepatosplenic T-cell lymphoma or adult T-cell leukemia/lymphoma

- Relapsed after prior salvage combination chemotherapy OR not a
candidate to receive such therapy

- Hodgkin's lymphoma

- Relapsed after prior salvage combination chemotherapy with or without
high-dose chemotherapy followed by autologous hematopoietic stem cell
rescue OR not a candidate to receive such therapy

- Acute lymphocytic leukemia meeting any of the following criteria:

- Relapsed during or after prior multi-agent combination chemotherapy
administered in sequential induction, consolidation, and maintenance
courses OR not a candidate to receive such therapy

- Relapsed after prior salvage combination chemotherapy with or without
high-dose chemotherapy followed by autologous hematopoietic stem cell
rescue OR not a candidate to receive such therapy

- Relapsed after prior chemotherapy with or without radiotherapy
followed by allogeneic hematopoietic stem cell transplant (or
ineligible for such therapy) AND demonstrates persistent cytogenetic,
fluorescent in situ hybridization (FISH), or molecular (reverse
transcriptase-polymerase chain reaction) evidence of bcr-abl fusion
gene despite 6 weeks of treatment with imatinib mesylate

- Acute myelogenous leukemia or myelodysplasia meeting any of the following
criteria:

- Relapsed or refractory disease after prior induction chemotherapy
(anthracycline and cytarabine, topotecan hydrochloride and cytarabine,
or comparable regimen) OR not a candidate to receive such therapy

- Not a candidate for chemotherapy with or without radiotherapy followed
by allogeneic or autologous hematopoietic stem cell transplant

- Patients with acute promyelomonocytic leukemia must have received
prior tretinoin and arsenic trioxide

- Chronic myelogenous leukemia meeting any of the following criteria:

- Relapsed or refractory disease after prior imatinib mesylate

- Not a candidate for chemotherapy with or without radiotherapy followed
by allogeneic hematopoietic stem cell transplant

- Chronic phase disease allowed if there is FISH or cytogenetic evidence
of increasing disease

- Solid tumor, including any of the following:

- Renal cell carcinoma

- Metastatic relapsed or refractory disease after prior high-dose
aldesleukin OR ineligible to receive such therapy due to comorbidities
OR did not consent to treatment

- Bladder cancer or gastric cancer

- Metastatic relapsed or refractory disease after prior combination
therapy OR not a candidate to receive such therapy

- Prostate cancer

- Metastatic relapsed or refractory disease after prior hormonal therapy
OR not a candidate to receive such therapy

- Testicular cancer

- Metastatic relapsed or refractory disease after prior standard
induction or salvage chemotherapy or high-dose chemotherapy with
autologous hematopoietic stem cell rescue OR not a candidate to
receive such therapy

- Pancreatic cancer

- Metastatic relapsed or refractory disease after prior gemcitabine
hydrochloride-based therapy OR not a candidate to receive such therapy

- Hepatocellular carcinoma

- Unresectable or metastatic disease

- Colorectal carcinoma

- Metastatic relapsed or refractory disease after prior combination
therapy, including fluorouracil with or without leucovorin calcium,
oxaliplatin, or irinotecan hydrochloride OR not a candidate to receive
such therapy

- Breast cancer meeting any of the following criteria:

- Metastatic relapsed or refractory disease after prior first- or
second-line standard combination chemotherapy OR not a candidate to
receive such therapy

- Received prior trastuzumab (Herceptin®) and sequential hormonal
therapy OR not a candidate to receive such therapy as indicated by the
biological characteristics of the cancer

- Lung cancer (non-small cell or small cell lung cancer), ovarian cancer,
endometrial cancer, or cervical cancer

- Metastatic relapsed or refractory disease after prior first- or
second-line combination chemotherapy OR not a candidate to receive
such therapy

- Malignant melanoma

- Metastatic relapsed or refractory disease after prior immunotherapy or
combination chemotherapy OR not a candidate to receive such therapy

- Sarcoma meeting any of the following criteria:

- Metastatic relapsed or refractory disease after prior first- or
second-line combination chemotherapy OR not a candidate to receive
such therapy

- Not a candidate for resection

- Patients with gastrointestinal stromal tumors must have received prior
imatinib mesylate

- Measurable disease

- Must have received prior available standard therapy for specific disease OR not a
candidate for this treatment

- No CNS malignancy

- HLA-partially matched (≥ 2/6 HLA antigen [A, B, DR]) related donor (above 18 years of
age) available

PATIENT CHARACTERISTICS:

- ECOG performance status 0-1

- Life expectancy > 3 months

- Bilirubin < 1.5 times upper limit of normal (ULN)

- AST < 3.0 times ULN

- LVEF > 35%

- No active infections

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- No uncontrolled medical or psychiatric illness that would preclude study compliance,
in the opinion of the investigator

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics