Randomized Phase 3 Trial for Patients With AML in CR2 Comparing Total Body Irradiation (TBI) With 8Gy/Fludarabine to Conditioning With TBI 12Gy/Cyclophosphamide

Inclusion Criteria:

- Patients with AML in second complete remission

- HLA-identical related (HLA * A, B, and DR) or HLA-compatible unrelated donor with
maximum of one Ag mismatch

- Ages 18-60 years

- Written informed consent from the patient

- Written informed consent from the donor

- No major organ dysfunction

Exclusion Criteria:

- Cardiac failure (New York Heart Association [NYHA] grade II-IV)

- Renal failure (creatinine > 2.0 mg/dl)

- Hepatic failure (total bilirubin > 3 mg/dl)

- Severe neurological/psychiatric disorder

- Previous allogeneic HSCT

- Contra-indications for used drugs

- HIV infection

- Non-compliance to processing of personal data according to the protocol