Efficacy of GSK Bio HPV Vaccine (580299) vs Hepatitis A Vaccine as Control in Prevention of Persistent HPV-16/18 Cervical Infection & Cervical Neoplasia, Administered Intramuscularly According to 0,1,6 Month Schedule in Healthy Females (15-25 Years)

Inclusion Criteria:

- A woman whom the investigator believes that she and/or her parents/legally acceptable
representative can and will comply with the requirements of the protocol (e.g.,
completion of the diary cards, return for follow-up visits).

- A woman between, and including, 15 and 25 years of age at the time of the first
vaccination.

- Written informed consent must be obtained from the subject prior to enrollment (for
subjects below the legal age of consent, written informed consent must be obtained
from a parent or legal guardian of the subject and, in addition, the subject should
sign and personally date a written informed assent).

- Subject must be free of obvious health problems as established by medical history and
clinical examination before entering into the study.

- Subject must have a negative urine pregnancy test.

- Subject must be of non-childbearing potential or, if of childbearing potential, she
must be abstinent or must be using adequate contraceptive precautions for 30 days
prior to the first vaccination and must agree to continue such precautions for two
months after completion of the vaccination series.

- Has had no more than 6 lifetime sexual partners prior to enrollment. This criterion
may not be applicable in subjects less than 18 years of age, according to local
regulatory/ethical requirements.

- Subject must have intact cervix.

Exclusion Criteria:

- Pregnant or breastfeeding. Women must be at least 3 months post-pregnancy and not
breastfeeding to enter the study.

- A woman planning to become pregnant or planning to discontinue contraceptive
precautions during approximately the first nine months of the study (Months 0-8).

- Previous administration of components of the investigational vaccine.

- Use of any investigational or non-registered product (drug or vaccine) other than the
study vaccine(s) within 30 days preceding the first dose of study vaccine, or planned
use during the study period.

- Chronic administration of immunosuppressants or other immune-modifying drugs within
six months prior to the first vaccine dose.

- Planned administration/administration of a vaccine not foreseen by the study protocol
within 30 days before and 30 days after (i.e. days 0-29) each dose of vaccine.
Administration of some routine vaccines up to 8 days before each dose of study
vaccine is allowed. Enrolment will be deferred until the subject is outside of
specified window.

- Previous vaccination against human papillomavirus (HPV).

- History of vaccination against Hepatitis A or a known clinical history of Hepatitis A
disease.

- History of having had colposcopy or has planned a colposcopy to evaluate an abnormal
cervical cytology (Pap smear) test.

- Any medically diagnosed or suspected immunodeficient condition based on medical
history and physical examination.

- History of allergic disease, suspected allergy or reactions likely to be exacerbated
by any component of the study vaccines.

- Hypersensitivity to latex.

- Known acute or chronic, clinically significant pulmonary, cardiovascular, neurologic,
hepatic or renal functional abnormality, as determined by previous physical
examination or laboratory tests.

- History of chronic condition(s) requiring treatment.

- Received immunoglobulins and/or blood product within 90 days preceding enrollment.
Enrollment will be deferred until the subject is outside of specified window.

- Acute disease at the time of enrolment.

- Heavy bleeding (menstruation or other) or heavy vaginal discharge in which a pelvic
exam cannot be performed. Enrollment will be deferred until condition is resolved
according to investigator's medical judgement.