Nonmyeloablative Allogeneic Stem Cell Transplantation For Relapsed Hodgkin's or Non-Hodgkin's Lymphoma After Autologous Transplantation ( A BMT Study)

Inclusion Criteria

DISEASE CHARACTERISTICS:

- Diagnosis of lymphoma of 1 of the following types:

- Diffuse large B-cell lymphoma

- Follicular lymphoma

- Grades 1, 2, or 3

- Primary mediastinal lymphoma

- Mantle cell lymphoma

- Small lymphocytic lymphoma

- Hodgkin's lymphoma

- Transformed lymphoma

- Relapsed after prior autologous bone marrow transplantation (BMT)

- More than 180 days post BMT

- Received ≥ 1 course of chemotherapy after BMT relapse

- Achieved a complete response OR a partial response to chemotherapy

- Largest residual tumor dimension ≤ 2 cm

- No clinical or laboratory evidence of CNS involvement by lymphoma

- HLA-identical donor available, meeting 1 of the following criteria:

- Sibling donor with 5/6 or 6/6 alleles matching by genotyping

- No monozygotic identical twins

- Unrelated donor with 10/10 alleles matching by genotyping

PATIENT CHARACTERISTICS:

Age

- 18 and over

Performance status

- Zubrod 0-2

Life expectancy

- Not specified

Hematopoietic

- Not specified

Hepatic

- Not specified

Renal

- Not specified

Cardiovascular

- LVEF ≥ 40% by MUGA or 2-D echocardiogram (2-D ECHO)

- No significant cardiac abnormalities by MUGA or 2-D ECHO

- No uncompensated coronary artery disease by ECG or physical exam

- None of the following within the past 6 months:

- Myocardial infarction

- Unstable angina

- Uncontrolled atrial fibrillation

- None of the following within the past 3 months:

- Severe peripheral vascular disease

- Venous stasis ulcers

- Deep venous or arterial thrombosis

- No uncontrolled hypertension

Pulmonary

- DLCO (corrected) and total lung capacity ≥ 40% of predicted

- No requirement for continuous supplemental oxygen

Other

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- HIV negative

- No AIDS

- No active bacterial, viral, or fungal infection

- No other malignancy within the past 5 years except adequately treated basal cell or
squamous cell skin cancer or carcinoma in situ of the cervix

- No history of uncontrolled seizures

- No diabetic ulcers within the past 3 months

PRIOR CONCURRENT THERAPY:

Biologic therapy

- See Disease Characteristics

- No more than 1 prior bone marrow transplantation

Chemotherapy

- See Disease Characteristics

- More than 21 days since prior chemotherapy and recovered

Endocrine therapy

- Not specified

Radiotherapy

- More than 4 weeks since prior radiotherapy

Surgery

- More than 4 weeks since prior major surgery except placement of a venous access
device