Inclusion Criteria:

- Diagnosis of relapsed or relapsed, refractory disease

- Age is greater or equal to 18 years at the time of signing the informed consent

- Eastern Cooperative Oncology Group (ECOG) performance status of 0-2

- Ability to adhere to the study visit schedule and all protocol requirements

- Voluntarily sign an informed consent

- All baseline studies must be completed for determining eligibility within 21 days of
study enrollment

- Women of child-bearing potential (WCBP) defined as a sexually mature woman who has
not undergone a hysterectomy or who has not been naturally post-menopausal for at
least 24 consecutive months must have a negative serum or urine pregnancy test prior
to each cycle of treatment

- All WCBP and all sexually active male patients must agree to use adequate methods of
birth control throughout the study

Exclusion Criteria:

- Disease specific treatment within the previous 3 weeks including use of chemotherapy
that is known to be active or may be active against multiple myeloma

- Previous treatment with 17-AAG, DMAG, or other known Hsp90 inhibitor

- Participation in any investigational drug study within 3 weeks preceding start of
treatment for conventional small molecule therapy or 4 weeks preceding the start of
treatment for biologic or vaccine therapy; concurrent radiation therapy is not
permitted

- Concomitant use of corticosteroids may not exceed prednisone 10 mg per day with the
exception of pre-medication for transfusion of blood products and topical application

- Concurrent treatment with any agent that alters CYP3A activity (unless maintained on
stable dose)

- Baseline QTc >450

- NYHA class 3 or 4 congestive heart failure

- Left Bundle Branch Block

- Mycardial infarction or active ischemic heart disease within 6 months

- Grade 3 or greater peripheral neuropathy

- Renal insufficiency, serum creatinine >2x upper limit of normal (ULN)

- Platelets < 30,000 mm3 or refractory to transfusion and unable to be maintained >
50,000 mm3

- AST and / or ALT > 2.0x ULN

- ANC <1,000 cells/mm3

- Hemoglobin < 8.0 g/dL

- Presence of active infection or systemic use of antibiotics within 72 hours of
treatment

- WCBP who are breast feeding

- Significant co-morbid condition or disease which in the judgment of the investigator
would place the patient at undue risk or interfere with the study (e.g. cardiac
disease such as acute coronary syndrome or unstable angina within 6 months, New York
Heart Association (NYHA) class 2 or greater congestive heart failure (CHF),
uncontrolled hypertension, arrhythmia requiring medication or mechanical control,
chronic obstructive pulmonary disease (COPD), cirrhotic liver disease, or other
conditions)