Randomized, Phase II,Open-Label Controlled Study of Two Different Doses and Schedules of EMD 72000 (Matuzumab) in Combination With Pemetrexed, or Pemetrexed Alone, as Second-Line Treatment for Stage IIIB/IV Non-Small Cell Lung Cancer and Progressive Disease on or After First-Line Treatment With a Platinum in Combination With Taxanes, Gemcitabine and Vinorelbine
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Independent radiological response rate
various timepoints measured
No
Joan Schiller, MD
Principal Investigator
University of Texas
United States: Food and Drug Administration
EMD 72000-031
NCT00111839
August 2005
March 2009
Name | Location |
---|---|
James Graham Brown Cancer Center | Louisville, Kentucky 40202 |
Rush University Medical Center | Chicago, Illinois 60612-3824 |
University of Missouri | Columbia, Missouri 65212 |
Georgia Cancer Specialists | Decatur, Georgia 30033 |
University of Minnesota | Minneapolis, Minnesota 55455 |
Sharp Memorial Hospital | San Diego, California 92123 |
Arizona Clinical Research Center | Tucson, Arizona 85712 |
Integrated Community Oncology Network | Jacksonville Beach, Florida 32250 |
Tyler Cancer Center | Tyler, Texas 75702 |
Cancer Care Northwest | Spokane, Washington 99202 |
University of North Carolina | Chapel Hill, North Carolina 27599 |
Deaconess Billings Clinic | Billings, Montana 59107-5100 |
Hematology-Oncology Clinic | Baton Rouge, Louisiana 70808 |
Holy Cross Hospital | Fort Lauderdale, Florida 33308 |
Henry Ford Health Systems | Detroit, Michigan 48202 |
Providence Portland Medical Center | Portland, Oregon 97213-3635 |
Dartmouth Hitchcock Medical Center | Lebanon, New Hampshire 03756 |
The Cleveland Clinic Foundation | Cleveland, Ohio |
Thomas Jefferson University Hospital | Philadelphia, Pennsylvania 19131 |
Louisville Oncology | Louisville, Kentucky 40202 |
Frederick Memorial Hospital | Frederick, Maryland 21701 |
West Michigan Regional Cancer and Blood Center | Ludington, Michigan 49431 |
Peachtree Hematology and Oncology | Atlanta, Georgia 40202 |
Hematology & Oncology Associates of NEPA | Dunmore, Pennsylvania 18512 |
University of Wisconsin | Madison,, Wisconsin 53792-5666 |
Northern Indiana Cancer Research Consortium | South Bend, Indiana |
Indiana Oncology Hematology Consultants | Indianapolis, Indiana 46202 |
Dayton Oncology and Hematology | Kettering, Ohio |
Kansas City Cancer Center | Kansas City, Kansas 66112 |
University of Arkansas, Arkansas Cancer Research Center | Little Rock, Arkansas 72205 |
University of Southern California/Norris Cancer Center | Los Angeles, California 90033 |
Cancer Center or Florida | Ocoee, Florida 34761 |
University of Illinois | Chicago, Illinois 60612 |
Cancer Care Specialists of Central Illinois | Decatur, Illinois 62256 |
Cancer Institute of Alexian Brothers | Elk Grove Village, Illinois 60007 |
Hematology-Oncology of Indiana PC | Indianapolis, Indiana 46260 |
Tuffs-New England Medical Center | Boston, Massachusetts 20111 |
Nebraska Hematology-Oncology, PC | Lincoln, Nebraska 68506 |
New York Oncology | Albany, New York 12208 |
Presbyterian Hospital Cancer Center | Charlotte, North Carolina 28204 |
Mary Crowley Research Center | Dallas, Texas 75246 |
Rainer Oncology Professional Services | Puyallup, Washington 98372 |