Inclusion Criteria:

- Patients must have a pathological diagnosis of Waldenstrom's Macroglobulinemia, with
advanced and/or symptomatic disease requiring therapy. At least one of the following
must be true: *Presence of cytopenias, defined as Hemoglobin < 11 gm%, or WBC <
2000/µl, or platelets < 100,000 µl; *Presence of extensive (>3 cm) or symptomatic
lymphadenopathy or hepatosplenomegaly; *Presence of B symptoms (night sweats, fever,
weight loss of >10% of the baseline); *Presence of severe neuropathy, not otherwise
explained; *Progressive disease (increase in "M" by > 50% while observed, and
decrease in hemoglobin by >2 gm%,and/or decrease in platelets by >50,000/µl, and/or
increase in lymphadenopathy); *Serum albumin <2.5 gm%; *Persistently elevated β-2M
>3.0 in the absence of renal impairment or active infection.

- Hyperviscosity will be treated (in addition to plasmapheresis) only in the presence
of any of the above

- All necessary baseline studies for determining eligibility must be obtained within 35
days prior to registration.

- Patients must have a performance status of 0-2 based on SWOG criteria. Patients with
a poor performance status (3-4), based solely on bone pain, will be eligible.

- Patients must not have significant co-morbid medical conditions or uncontrolled life
threatening infection.

- Patients with recent (< 6 months) myocardial infarction, unstable angina, difficult
to control congestive heart failure, uncontrolled hypertension, or difficult to
control cardiac arrythmias are ineligible. Ejection fraction by ECHO must be > 50%
and must be performed within 60 days prior to registration, unless the patient has
received chemotherapy within that period of time (dexamethasone and thalidomide
excluded), in which case the LVEF must be repeated.

- Patients must have a creatinine < 3 mg/dl and a creatinine clearance > 30 ml/minute.
Patients with a creatinine clearance of 30-50 ml will only receive a 50% cisplatin
dose.

- Patients must have adequate hepatic function defined as serum transaminases < 2 x ULN
and direct bilirubin < 2.0 mg/dl.

- Patients must be able to receive full doses of DT PACE, in the opinion of the
treating investigator, with the exception of: *Patients that have received prior
adriamycin > 450 mg/m2 and LVEF < 55%. Adriamycin will be omitted in these patients;
*Patients with a creatinine clearance 30 - 50 ml/minute, who will receive 50% of the
cisplatin dose.

- Patients must not have a history of chronic obstructive or chronic restrictive
pulmonary disease. Patients must have adequate pulmonary function studies > 50% of
predicted on mechanical aspects (FEV1, FVC, etc) and diffusion capacity (DLCO) > 50%
of predicted. Patients unable to complete pulmonary function tests due to myeloma
related pain or fracture must have a high resolution CT scan of the chest and must
also have acceptable arterial blood gases defined as PO2 greater than 70.

Exclusion Criteria:

- No prior malignancy is allowed except for adequately treated basal cell or squamous
cell skin cancer, in situ cervical cancer, or other cancer for which the patient has
been disease free for at least three years. Prior malignancy is acceptable provided
there has been no evidence of disease within the three-year interval.

- Pregnant or nursing women may not participate. Women of childbearing potential must
have a negative pregnancy test documented within one week of registration. Women/men
of reproductive potential may not participate unless they have agreed to use an
effective contraceptive method.

- All patients must be informed of the investigational nature of this study and must
sign and give written informed consent in accordance with institutional and federal
guidelines.