Inclusion Criteria:

- Relapsed or refractory solid tumors not curable with standard therapy.

- At least one measurable lesion

- ECOG Performance Status less than or equal to 2

- Acceptable hematologic status

- Albumin greater than or equal to 2.5 g/dL

- Normal calculated glomerular filtration rate (GFR)

- Acceptable liver function

Exclusion Criteria:

- Uncontrolled cardiac disease, angina, congestive heart failure, or myocardial
infarction within 6 months prior to Study Day

- Known history of hepatitis B or C, or HIV infection

- Clinically significant effusions, including pericardial, pleural, and ascites

- Serious non-malignant disease

- Central nervous system (CNS) metastatic involvement except where the disease has been
successfully treated

- Investigational therapies within 4 weeks of Study Day 1

- Radiation therapy of tumors to be followed for this study

- Chemotherapy, biologic therapy, or major surgery other than diagnostic within 4 weeks
prior to Study Day 1

- Current Grade 3 or 4 neurological toxicity

- Concurrent anti-neoplastic therapy and/or steroids