Metabolic Adaptations to Six Month Caloric Restriction
25 Years
50 Years
Both
Aging, Cardiovascular Disease, Diabetes Mellitus
Trial Information
Metabolic Adaptations to Six Month Caloric Restriction
This study tests whether chronic caloric restriction improves risk factors of longevity in
humans as it is known to do in animals, by measuring a variety of factors dealing with
metabolism and oxidative stress, through physical evaluations and laboratory tests.
Participants will receive dietary counseling and free medical evaluations. In addition,
each volunteer will be asked to do one of the following:
1. Follow a reduced calorie diet
2. Follow a reduced calorie diet using a liquid diet
3. Increase physical activity while on a reduced calorie diet
4. Follow a standard diet.
Three separate five-day inpatient stays are required.
Inclusion Criteria:
- Resident of greater Baton Rouge area for 1 year or longer
- Men between ages 25-50
- Women between ages 25-45
- Body Mass Index (BMI) between 25-30 (never having had BMI greater than 32)
- Healthy, non-smokers with no history of cardiovascular disease, high blood pressure,
diabetes, eating disorder, or major psychiatric disorder
Exclusion Criteria:
- Pregnant or breastfeeding
- Personal history of cardiovascular disease or elevated high blood pressure (higher
than 160/90 mmHg)
- Abnormal electrocardiogram (EKG)
- Personal history of diabetes
- Personal history of major psychiatric disorders
- Personal history of eating disorder
- Smoking
- Exercising regularly (more than twice a week)
- Individuals with alcoholism or other substance abuse
- Post obese (never have had a BMI greater than 32)
- Regular use of medications, except oral contraceptives
- Individuals who were ever injured by a metallic foreign body which was not removed
- Individuals who wear braces on their teeth, have non-removable false teeth, or
non-removable bridgework
- Individuals in occupations requiring full alertness and motor skills (airline pilots,
etc.) where even a small chance of postural dizziness would be unacceptable.
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Prevention
Principal Investigator
Eric Ravussin, Ph.D.
Investigator Role:
Principal Investigator
Investigator Affiliation:
Pennington Biomedical Research Center
Authority:
United States: Federal Government
Study ID:
AG0005
NCT ID:
NCT00099151
Start Date:
March 2002
Completion Date:
May 2006
Related Keywords:
- Aging
- Cardiovascular Disease
- Diabetes Mellitus
- Longevity
- Dietary restriction
- Physical activity
- Weight Loss
- Diabetes
- Cardiovascular Diseases
- Diabetes Mellitus
Name | Location |
|---|---|
| Pennington Biomedical Research Center, 6400 Perkins Road | Baton Rouge, Louisiana 70808 |
