Inclusion Criteria:

- Signed Informed Consent and Authorization document

- Metastatic, or locally advanced and unresectable, adenocarcinoma of the colon or
rectum

- Receiving Avastin as a component of first-line chemotherapy

- First-line chemotherapy plus Avastin initiated <=4 months prior to enrollment in the
study

Exclusion Criteria:

- Patients who have contraindications for treatment with Avastin (see the Avastin
Package Insert) or who would incur excessive risks with Avastin treatment are
ineligible for this study.