An Open-Label, Clinical Trial Evaluating the Safety and Pharmacokinetics of Two Dose Schedules of Panitumumab in Subjects With Advanced Solid Tumors

Inclusion Criteria:

- Pathologic diagnosis of advanced solid tumors that are refractory to at least 1
standard therapy or for which no standard therapy is available and have not received
more than 3 prior treatment regimens (not inclusive of hormonal therapies for breast
and prostate cancer subjects) for the advanced solid tumor (tumor must be diagnosed
by standard criteria for the specific tumor type)

- Measurable disease or evaluable (non-measurable) disease per RECIST guidelines (all
sites of disease must be evaluated within 28 days before enrollment)

- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

- Life expectancy of > 3 months as documented by the investigator

- If history of other primary cancer, subject will be eligible only if she or he has:

- Non-melanomatous skin cancer, not requiring treatment

- Curatively treated cervical carcinoma in situ

- Other primary solid tumor curatively treated with no known active disease
present for the last 5 years and no treatment administered for the last 3 years

- Man or woman 18 years of age or older

- Paraffin-embedded tumor tissue (from primary or metastatic tumor tissue) available
for immunohistochemistry studies of EGFr expression (biopsy or archived tissue are
acceptable). The immunohistochemical EGFr staining and evaluation must be conducted
at the designated central laboratory using the DakoCytomation EGFR pharmDXTM kit.
Local laboratory EGFr expression is not permitted for the purpose of eligibility in
this study

- Hematologic function, as follows:

- Absolute neutrophil count (ANC) > 1.5 x 109/L

- Platelet count > 100 x 109/L

- Hemoglobin > 8 g/dL

- Renal function, as follows:

o Creatinine < 2.0 mg/dL

- Hepatic function, as follows:

- Aspartate aminotransferase (AST) < 3 x ULN (if liver metastases ≤ 5 x ULN)

- Alanine aminotransferase (ALT) < 3 x ULN (if liver metastases ≤ 5 x ULN)

- Bilirubin < 2 x ULN

- Competent to comprehend, sign, and date an IEC/IRB-approved informed consent form