Inclusion Criteria:

- MM patients who have active, symptomatic myeloma, and meet the criteria below thus
establishing the presence of high-risk myeloma

- MM Salmon-Durie Stage: IA&B (with abnormal cytogenetics*), IIA, IIB, IIIA, and IIIB,
and meet the criteria below thus establishing the presence of high-risk myeloma

- MM must meet one of the following criteria: a) Patients who have MAGE-A3 positive MM
and who have the tissue type HLA-A*0101, or -* B35, are allocated to receive the
MAGE-A3168-176 peptide vaccine. b) Patients who have NY-ESO-1 positive MM and who
have the tissue type HLA-A*0201 are allocated to the NY-ESO-1156-C165V peptide
vaccine. c) Patients who have NY-ESO-1 positive and MAGE-A3 negative or positive MM
and who have as tissue type HLA-A*0101, or -* B35 and HLA-A*0201, will receive
vaccination with the NY-ESO-1156-C165V peptide vaccine. d) Patients who have NY-ESO-1
negative and MAGE-A3 positive MM and who have as tissue type HLA-A*0101, or -* B35
and HLA-A*0201, will receive vaccination with the MAGE-A3 peptide vaccine.

- Karnofsky performance score ≥=70, unless bone pain caused by MM results in a
Karnofsky score of > or =50.

- Age 18-70 years old

- Hb > or =8.0gm/dl, ANC > or =1,000/microliters, platelet count > or =
100,000/microliters.

- Patients must have signed an IRB-approved consent form and been informed about the
investigational nature of the study

- Negative serology for HIV, Hepatitis C and negative for Hepatitis B surface antigen.

- CD4+ count >400/microliters

- Life expectancy > 6 months

- Negative pregnancy test and females agree to two forms of contraception or
abstinence.

- Provisional insurance approval for single or double auto-transplant(s)

Exclusion Criteria:

- MGUS, indolent and smoldering myeloma

- Chemotherapy or other immunosuppressive treatment e.g. gluco-corticosteroids,
cyclophosphamide, methotrexate within the 4 weeks prior to enrollment

- Patients who have malignancies other than carcinoma-in-situ of the cervix or
non-melanomatous skin cancer

- Fever or active infection

- Liver function: total bilirubin > 2.5xULN or AST/ALT >2.5xULN

- Renal function: patients on dialysis, or serum creatinine >2.0mg/dl

- Simultaneous treatment with a second investigational drug or biologic agent for MM

- Other intercurrent serious illness, e.g. cardiac, pulmonary, hepatic disease,
uncontrolled diabetes, etc

- Cardiac: Patients with recent (< or =6 months) myocardial infarction, unstable
angina, difficult to control congestive heart failure, uncontrolled hypertension, or
difficult to control cardiac arrythmias are ineligible. Ejection fraction by ECHO or
must be > or = 50% and must be performed within 60 days prior to registration, unless
the patient has received chemotherapy within that period of time (dexamethasone and
thalidomide excluded), in which case the LVEF must be repeated

- Pulmonary: Patients must not have a history of chronic obstructive or chronic
restrictive pulmonary disease resulting in unacceptable lung function: patients must
have adequate pulmonary function studies > or = 50% of predicted on mechanical
aspects (FEV1, FVC, etc) and diffusion capacity (DLCO) > or = 50% of predicted.
Patients unable to complete pulmonary function tests due to myeloma related pain or
fracture must have a high resolution CT scan of the chest and must also have
acceptable arterial blood gases defined as P02 greater than 70

- Patients must be able to receive full doses of DT PACE, in the opinion of the
treating investigator, with the exception of: A) Patients that have received prior
adriamycin > 450 mg/m2 and LVEF < 55%. Adriamycin will be omitted in these patients.
B) Patients with a creatinine clearance 30 - 50 ml/minute, who will receive 50% of
the cisplatin dose