Providing Genetic And Environmental Cancer Risk Assessment In Primary Care

Trial Information

Providing Genetic And Environmental Cancer Risk Assessment In Primary Care

OBJECTIVES:

Part 1

- Determine the willingness of healthy participants to enroll in a genetic and
environmental risk assessment for colorectal cancer.

- Determine the impact of decision counseling on knowledge and attitudes about genetic
and environmental risk assessment (GERA) and colorectal cancer screening in these
participants.

- Determine participants' understanding of GERA.

- Determine participants' response to GERA results.

Part 2

- Determine awareness of, and interest in, diet and genetic assessment for colorectal
cancer among healthy participants at average risk for colorectal cancer who have not
undergone regular colon cancer screening.

- Determine participants' level of knowledge of this assessment.

- Determine participants' rate of acceptance into this study.

OUTLINE: This is a 2-part pilot study.

- Part 1: Participants complete a baseline questionnaire on attitudes, beliefs, and
knowledge about colorectal cancer (CRC), CRC screening, and diet and genetic testing
for colorectal cancer risk. Two-four weeks later, participants are educated about CRC
screening options and undergo genetic and environmental risk assessment (GERA) decision
counseling about the methylene tetrahydrofolate reductase (MTHFR) gene and dietary
folate intake. Participants who decide to undergo GERA undergo blood testing for MTHFR
polymorphisms and folate levels. Participants whose blood tests indicate low folate
levels are further counseled about dietary folate intake.

- Part 2: Participants complete a questionnaire on attitudes, beliefs, and knowledge
about CRC, CRC screening, and diet and genetic testing for colorectal cancer risk.

Participants in part 1 are followed at 1 week, 1 month, and then at 6 months.

PROJECTED ACCRUAL: A total of 110 participants (60 for part 1 and 50 for part 2) will be
accrued for this study.