Inclusion Criteria:

- Patients with a diagnosis of local unresectable HCC confirmed by histology using fine
needle aspirate (FNA) or liver biopsy. "Local" is defined as disease either
restricted to the liver or contiguous with the liver and no identifiable extrahepatic
disease.

- Patients with Child-Pugh Class A liver function. For purposes of this trial, an
eligible patient must not have Encephalopathy or Ascites and the total Child-Pugh
score cannot be greater than 6 at baseline

- Males or females 18 years of age or older

- Ability to provide written informed consent before initiation of any study-related
procedures and ability, in the opinion of the Principal Investigator, to comply with
all the requirements of the study

- Male and female subjects who are surgically sterile, who remain abstinent, or who
agree to practice double barrier forms of birth control from screening through 30
days (females) and 90 days (males), from the last dose of study medication

Exclusion Criteria:

- History of or presence of clinically significant acute or unstable cardiovascular,
cerebrovascular (stroke), renal, GI, pulmonary, immunological (with the exception of
the presence of hepatitis B virus [HBV], HCV hepatitis, or cirrhosis), endocrine, or
central nervous system disorders

- Patient has a history of cancer other than hepatocellular (excluding resected basal
cell carcinoma; or curatively resected stage 1 or less cervical cancer if disease
free for 5 years or more).

- Patients with distant metastasis or extrahepatic disease

- An Eastern Cooperative Oncology Group (ECOG) performance status score of greater than
or equal to 2

- Current encephalopathy or current treatment for encephalopathy

- History of drug or alcohol abuse within 6 months before screening

- History of, or current clinically significant mental disorder or an antagonistic
personality that compromises the validity of the informed consent

- A documented variceal hemorrhage within 4 months of screening

- Neutrophil count less than or equal to 1,500/mm3, platelet count less than or equal
to 100,000/mm3, hemoglobin less than or equal to 8.5 g/dL, or a Prothrombin Time
(INR) greater than 1.3 (vitamin K supplementation allowed)

- Serum creatinine greater than 1.1 times the upper limit of normal

- History of human immunodeficiency virus or acquired immune deficiency syndrome

- Use of an investigational drug or product or participation in a drug study within 30
days before dosing

- Liver function defined as: serum bilirubin greater than 1.5 times the upper limit of
normal or an aspartate aminotransferase (AST) or alanine aminotransferase (ALT)
greater than 5 times upper limit of normal, or serum albumin less than 3.2 g/dL

- History of gout or abnormal uric acid metabolism

- The clinical presence of ascites

- Treatment of HCC within 30 days of screening by chemotherapy or treatment of the
target lesion(s) by chemoembolization, PEI, or surgery

- Radiofrequency ("RF") ablation of the target lesion(s) within 60 days of screening

- Subjects with a life expectancy of less than 12 weeks

- Subjects having received an organ transplant

- Subjects currently receiving coumadin or heparin

- Pregnant or nursing women