Evaluation of HIV-Specific Immunological and Virological Responses of HIV-1 Multiply-Exposed Seronegative Individuals
18 Years
60 Years
Both
HIV Infections
Trial Information
Evaluation of HIV-Specific Immunological and Virological Responses of HIV-1 Multiply-Exposed Seronegative Individuals
Rare individuals appear naturally resistant to overt HIV-1 infection despite repeated sexual
exposures. These individuals, referred to as exposed seronegatives (ES), represent a unique
population in which to evaluate mechanisms by which HIV-1 replication is either controlled
or aborted. The purpose of the study is to analyze HIV-specific immune responses, both
cellular and humoral, that exist in seronegative individuals who have experienced multiple
exposures to HIV by sexual contact.
This study will follow participants for 2 years. Participants will have 25 study visits
during the study. Assessments will include HIV tests, viral load measurements, CD4 counts,
pregnancy tests, and physical exams.
Inclusion Criteria:
- Good general health
- HIV uninfected
- Repeated exposures to HIV through unprotected sexual intercourse within the 2 years
prior to study entry
- Live in the greater Seattle area
- Plan to stay in the greater Seattle area for the 2 years after study entry
Exclusion Criteria:
- Pregnancy
Type of Study:
Observational
Study Design:
Observational Model: Defined Population, Observational Model: Natural History, Time Perspective: Longitudinal, Time Perspective: Prospective
Principal Investigator
Julie McElrath, MD, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
University of Washington
Authority:
United States: Federal Government
Study ID:
5R01AI47086-03
NCT ID:
NCT00069485
Start Date:
December 1995
Completion Date:
Related Keywords:
- HIV Infections
- HIV Seronegativity
- HIV Infections
- Acquired Immunodeficiency Syndrome
Name | Location |
|---|---|
| Fred Hutchinson Cancer Research Center / University of Washington HIV Vaccine Trials Unit | Seattle, Washington 98104 |
