A Phase II Study Of Accelerated High Dose Thoracic Irradiation With Concurrent Chemotherapy For Patients With Limited Small Cell Lung Cancer
OBJECTIVES:
- Determine the response rate of patients with limited stage small cell lung cancer
treated with cisplatin and etoposide combined with accelerated high-dose thoracic
radiotherapy.
- Determine the progression-free and overall survival in patients treated with this
regimen.
- Determine the qualitative and quantitative toxicity and reversibility of toxicity of
this regimen in these patients.
OUTLINE: Patients undergo radiotherapy once daily 5 days a week for approximately 3 weeks
and then twice daily 5 days a week for approximately 2 weeks (a total of 9 treatment days
during the final 2-week treatment period). Beginning on the first day of radiotherapy,
patients receive cisplatin IV over 2 hours and etoposide IV over 1 hour on day 1 and oral
etoposide once daily on days 2 and 3. Chemotherapy repeats every 3 weeks for up to 4 courses
in the absence of disease progression or unacceptable toxicity.
Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then
annually thereafter.
PROJECTED ACCRUAL: A total of 71 patients will be accrued for this study within 18 months.
Interventional
Masking: Open Label, Primary Purpose: Treatment
Overall survival at 1 and 2 years
No
Ritsuko U. Komaki, MD, FACR
Study Chair
M.D. Anderson Cancer Center
United States: Federal Government
CDR0000271939
NCT00066222
June 2003
Name | Location |
---|---|
Akron City Hospital | Akron, Ohio 44304 |
Barbara Ann Karmanos Cancer Institute | Detroit, Michigan 48201 |
Hurley Medical Center | Flint, Michigan 48503 |
CCOP - Illinois Oncology Research Association | Peoria, Illinois 61602 |
CCOP - Michigan Cancer Research Consortium | Ann Arbor, Michigan 48106 |
Oakwood Cancer Center at Oakwood Hospital and Medical Center | Dearborn, Michigan 48123-2500 |
Genesys Hurley Cancer Institute | Flint, Michigan 48503 |
Van Elslander Cancer Center at St. John Hospital and Medical Center | Grosse Pointe Woods, Michigan 48236 |
Foote Hospital | Jackson, Michigan 49201 |
Bronson Methodist Hospital | Kalamazoo, Michigan 49007 |
West Michigan Cancer Center | Kalamazoo, Michigan 49007-3731 |
Borgess Medical Center | Kalamazooaa, Michigan 49001 |
Sparrow Regional Cancer Center | Lansing, Michigan 48912-1811 |
Seton Cancer Institute - Saginaw | Saginaw, Michigan 48601 |
St. John Macomb Hospital | Warren, Michigan 48093 |
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center | La Crosse, Wisconsin 54601 |
Rapid City Regional Hospital | Rapid City, South Dakota 57709 |
CCOP - Bay Area Tumor Institute | Oakland, California 94609-3305 |
Memorial Hospital of South Bend | South Bend, Indiana 46601 |
Veterans Affairs Medical Center - Dayton | Dayton, Ohio 45428 |
CCOP - Dayton | Kettering, Ohio 45429 |
Reading Hospital and Medical Center | Reading, Pennsylvania 19612-6052 |
CCOP - MainLine Health | Wynnewood, Pennsylvania 19096 |
LDS Hospital | Salt Lake City, Utah 84143 |
CCOP - Northern Indiana CR Consortium | South Bend, Indiana 46601 |
Saint Joseph Regional Medical Center | South Bend, Indiana 46617 |
Siteman Cancer Center at Barnes-Jewish Hospital | Saint Louis, Missouri 63110 |
Charles M. Barrett Cancer Center at University Hospital | Cincinnati, Ohio 45267-0526 |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore, Maryland 21231-2410 |
Cleveland Clinic Taussig Cancer Center | Cleveland, Ohio 44195 |
Utah Valley Regional Medical Center - Provo | Provo, Utah 84604 |
Markey Cancer Center at University of Kentucky Chandler Medical Center | Lexington, Kentucky 40536-0084 |
Josephine Ford Cancer Center at Henry Ford Hospital | Detroit, Michigan 48202 |
M.D. Anderson Cancer Center at University of Texas | Houston, Texas 77030 |
Comprehensive Cancer Center at University of Alabama at Birmingham | Birmingham, Alabama 35294 |
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center | Savannah, Georgia 31403-3089 |
Aultman Hospital Cancer Center at Aultman Health Foundation | Canton, Ohio 44710-1799 |
St. Agnes Cancer Center | Baltimore, Maryland 21229 |
Wayne Memorial Hospital, Incorporated | Goldsboro, North Carolina 27534 |
Cottonwood Hospital Medical Center | Murray, Utah 84107 |
McKay-Dee Hospital Center | Ogden, Utah 84403 |
Utah Cancer Specialists at UCS Cancer Center | Salt Lake City, Utah 84106 |
Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph | Saint Joseph, Michigan 49085 |
Paoli Memorial Hospital | Paoli, Pennsylvania 19301-1792 |
Elkhart General Hospital | Elkhart, Indiana 46515 |
Hillcrest Cancer Center at Hillcrest Hospital | Mayfield Heights, Ohio 44124 |
Eden Medical Center | Castro Valley, California 94546 |
Saint Rose Hospital | Hayward, California 94545 |
Highland General Hospital at St. George's University School of Medicine | Oakland, California 94602 |
Alta Bates Summit Medical Center - Summit Campus | Oakland, California 94609 |
Valley Care Medical Center | Pleasanton, California 94588 |
J.C. Robinson, M.D. Regional Cancer Center | San Pablo, California 94806 |
St. Joseph Medical Center | Bloomington, Illinois 61701 |
Graham Hospital | Canton, Illinois 61520 |
Memorial Hospital | Carthage, Illinois 62321 |
Eureka Community Hospital | Eureka, Illinois 61530 |
Galesburg Cottage Hospital | Galesburg, Illinois 61401 |
Galesburg Clinic | Galesburg, Illinois 61401 |
Mason District Hospital | Havana, Illinois 62644 |
Kewanee Hospital | Kewanee, Illinois 61443 |
McDonough District Hospital | Macomb, Illinois 61455 |
BroMenn Regional Medical Center | Normal, Illinois 61761 |
Community Cancer Center | Normal, Illinois 61761 |
Community Hospital of Ottawa | Ottawa, Illinois 61350 |
Oncology Hematology Associates of Central Illinois, PC - Ottawa | Ottawa, Illinois 61350 |
Cancer Treatment Center at Pekin Hospital | Pekin, Illinois 61554 |
Oncology Hematology Associates of Central Illinois, PC - Peoria | Peoria, Illinois 61615 |
OSF St. Francis Medical Center | Peoria, Illinois 61637 |
Illinois Valley Community Hospital | Peru, Illinois 61354 |
Perry Memorial Hospital | Princeton, Illinois 61356 |
St. Margaret's Hospital | Spring Valley, Illinois 61362 |
St. Francis Hospital and Health Centers - Beech Grove Campus | Beech Grove, Indiana 46107 |
Howard Community Hospital at Howard Regional Health System | Kokomo, Indiana 46904 |
Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte, Indiana 46350 |
St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital | Ann Arbor, Michigan 48106-0995 |
Fox Chase Cancer Center at St. Francis Medical Center | Trenton, New Jersey 08629 |
Wayne Radiation Oncology | Goldsboro, North Carolina 27534 |
Samaritan North Cancer Care Center | Dayton, Ohio 45415 |
Grandview Hospital | Dayton, Ohio 45405 |
David L. Rike Cancer Center at Miami Valley Hospital | Dayton, Ohio 45409 |
Good Samaritan Hospital | Dayton, Ohio 45406 |
Charles F. Kettering Memorial Hospital | Kettering, Ohio 45429 |
Middletown Regional Hospital | Middletown, Ohio 45044 |
UVMC Cancer Care Center at Upper Valley Medical Center | Troy, Ohio 45373-1300 |
Ruth G. McMillan Cancer Center at Greene Memorial Hospital | Xenia, Ohio 45385 |
Bryn Mawr Hospital | Bryn Mawr, Pennsylvania 19010 |
Lankenau Cancer Center at Lankenau Hospital | Wynnewood, Pennsylvania 19096 |
Dixie Regional Medical Center - East Campus | Saint George, Utah 84770 |
Wendt Regional Cancer Center at Finley Hospital | Dubuque, Iowa 52001 |
Cancer Treatment Center at the Medical Center - Bowling Green | Bowling Green, Kentucky 42101 |
South Jersey Healthcare Regional Cancer Center | Millville, New Jersey 08332 |
Huron Hospital Cancer Care Center | Cleveland, Ohio 44112 |
Euclid Hospital | Cleveland, Ohio 44119 |
Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford | Salem, Ohio 44460 |
South Pointe Hospital Cancer Care Center | Warrensville Heights, Ohio 44122 |
Cancer Treatment Center | Wooster, Ohio 44691 |
Schiffler Cancer Center at Wheeling Hospital | Wheeling, West Virginia 26003 |
Saint Louis University Cancer Center | Saint Louis, Missouri 63110 |
Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center | Pomona, California 91767 |
Wilmed Radiation Oncology Services | Wilson, North Carolina 27893 |
Columbia St. Mary's Cancer Care Center | Milwaukee, Wisconsin 53211 |
J. Phillip Citta Regional Cancer Center at Community Medical Center | Toms River, New Jersey 08755 |
Veterans Affairs Medical Center - Milwaukee | Milwaukee, Wisconsin 53295 |
Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center | Plattsburgh, New York 12901 |