The Natural History of Childhood Malignancies Treated With Radiation Therapy

Inclusion Criteria

- INCLUSION CRITERIA:

Patients who are evaluated by the Radiation Oncology Branch and are:

Children with cancer (or a precancer syndromes, such as aplastic anemia or other
myelodysplastic syndromes), between the age(s) of 6 months - 21 years, whose cancer (or
precancer syndrome) will be treated with radiation therapy in the Radiation Oncology
Branch, NCI.

Patients with cancer (or a precancer syndromes, such as aplastic anemia or other
myelodysplastic syndromes), who present with disease manifestations of special interest to
Radiation Oncology Branch investigators, because they are likely to shed led light on the
natural history, pathogenesis, radiation response, and late effects of disease process.

Patients with cancer (or precancer syndromes, such as aplastic anemia or other
myelodysplastic syndromes) who offer an important educational benefit to trainees in
radiation oncology and staff.

Patient must have a primary physician in the community who specializes in pediatrics
and/or oncology and is willing to collaborate with the ROB staff in the clinical
management of the patient

If indicated, availability of a parent or legal guardian to give informed consent

Children with cancer (or a precancer syndrome, such as aplastic anemia or other
myelodysplastic syndrome), between the age(s) of 6 months - 21 years, whose cancer (or
precancer syndrome) have already been treated with radiation therapy in the Radiation
Oncology Branch, NCI.

EXCLUSION CRITERIA:

Patients, and/or guardians who are in the estimation of the PI, deemed unable or unlikely
to adhere to protocol treatment and follow-up requirements.

Patients who are enrolled on a clinical trial (e.g. COG or CNMC) in which one of the
research objectives is to study the radiation treatment.

Patients who are pregnant and are to receive radiation treatment on this protocol.