A Phase II Study of Triapine in Combination With Gemcitabine in Patients With Pancreatic Cancer


Phase 2
18 Years
N/A
Not Enrolling
Both
Pancreatic Cancer

Thank you

Trial Information

A Phase II Study of Triapine in Combination With Gemcitabine in Patients With Pancreatic Cancer


OBJECTIVES:

- Determine the objective response rate (partial and complete response) in patients with
unresectable or metastatic pancreatic cancer treated with 3-AP and gemcitabine.

- Determine the progression-free interval and survival of patients treated with this
regimen.

- Determine the safety and feasibility of this regimen in these patients.

OUTLINE: This is a multicenter study.

- Stage I: Patients receive 3-AP IV over 4 hours and gemcitabine IV over 30 minutes on
days 1, 8, and 15. Treatment repeats every 4 weeks for up to 12 courses in the absence
of disease progression or unacceptable toxicity.

- Stage II: Patients receive a higher dose of 3-AP IV continuously over 24 hours on days
1, 8, and 15. Within 1 hour of completing 3-AP administration, patients receive
gemcitabine IV over 30 minutes on days 2, 9, and 16. Treatment repeats every 4 weeks
for up to 12 courses in the absence of disease progression or unacceptable toxicity.

Patients are followed at 1 month, every 2 months for 6 months, and then every 3 months for
18 months.

PROJECTED ACCRUAL: A total of 50-95 patients will be accrued for this study within 18-24
months.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Histologically or cytologically confirmed pancreatic cancer

- Unresectable or metastatic disease

- Measurable disease

- Outside prior radiation ports OR within prior radiation port if evidence of
disease progression after radiotherapy

- No CNS metastases

PATIENT CHARACTERISTICS:

Age

- 18 and over

Performance status

- ECOG 0-2

Life expectancy

- More than 3 months

Hematopoietic

- Absolute neutrophil count at least 1,500/mm^3

- Platelet count at least 100,000/mm^3

- Hemoglobin at least 9 g/dL (transfusion allowed)

Hepatic

- Bilirubin no greater than 2.0 mg/dL

- AST and ALT no greater than 3 times upper limit of normal (ULN) (5 times ULN in the
presence of liver metastases)

- Chronic viral hepatitis allowed

Renal

- Creatinine no greater than 2.0 mg/dL

Cardiovascular

- No myocardial infarction within the past 3 months

- No uncontrolled congestive heart failure

- No uncontrolled coronary artery disease

- No uncontrolled arrhythmias

Pulmonary

- No dyspnea at rest

- No dependence on supplemental oxygen

Other

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for 3 months after study
participation

- No other malignancy except any of the following:

- Carcinoma in situ of the cervix treated with cone biopsy or resection

- Nonmetastatic basal cell or squamous cell skin cancer

- Any stage I malignancy curatively resected more than 5 years ago

- No active infection

- No known or suspected glucose-6-phosphate dehydrogenase deficiency

- No other concurrent life threatening illness

PRIOR CONCURRENT THERAPY:

Biologic therapy

- Prior vaccines, antibodies, cytokines, or small molecule cell signaling inhibitors
allowed

Chemotherapy

- No prior cytotoxic chemotherapy for unresectable or metastatic pancreatic cancer

Endocrine therapy

- Not specified

Radiotherapy

- See Disease Characteristics

- More than 4 weeks since prior radiotherapy and recovered

- No concurrent radiotherapy

Surgery

- More than 3 weeks since prior surgery and recovered

Other

- More than 3 weeks since prior noncytotoxic treatment regimens and objective evidence
of progressive disease

- No other concurrent investigational drugs

Type of Study:

Interventional

Study Design:

Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Objective response rate (partial and complete response) as assessed by RECIST criteria

Safety Issue:

No

Principal Investigator

Mario Sznol, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Vion Pharmaceuticals

Authority:

United States: Federal Government

Study ID:

CDR0000306461

NCT ID:

NCT00064051

Start Date:

January 2003

Completion Date:

Related Keywords:

  • Pancreatic Cancer
  • stage II pancreatic cancer
  • stage III pancreatic cancer
  • recurrent pancreatic cancer
  • stage IV pancreatic cancer
  • Pancreatic Neoplasms

Name

Location
University of Chicago Cancer Research Center Chicago, Illinois  60637
University of Minnesota Cancer Center Minneapolis, Minnesota  55455
Sarah Cannon Cancer Center at Centennial Medical Center Nashville, Tennessee  37203
Indiana Oncology Hematology Consultants Indianapolis, Indiana  46202