A Phase I Study Of Low-Dose Subcutaneous Interleukin 2 (IL-2) And Stem Cell Factor (r-metHuSCF) For Patients With AIDS And AIDS-Associated Malignancy
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of HIV-1 by ELISA, Western blot, polymerase chain reaction, or other
documentation
- Must have had 1 of the following AIDS-defining illnesses:
- Opportunistic infection
- Opportunistic malignancy (excluding CNS involvement)
- CD4 T-cell count less than 200/mm^3 (but currently greater than 20/mm^3)
- Receiving antiretroviral therapy
- No concurrent Kaposi's sarcoma
- Prior Kaposi's sarcoma in complete response allowed
PATIENT CHARACTERISTICS:
Age
- 18 and over
Performance status
- Karnofsky 80-100%
Life expectancy
- Not specified
Hematopoietic
- Absolute granulocyte count greater than 1,000/mm^3*
- Hemoglobin at least 10 g/dL*
- Platelet count greater than 50,000/mm^3* NOTE: *Transfusions and growth factors
allowed in order to increase or maintain counts
Hepatic
- No major hepatic dysfunction evidenced by encephalopathy, ascites, or varices
- Bilirubin no greater than 2 mg/dL
- INR no greater than 1.5
Renal
- Not specified
Cardiovascular
- No prior angioedema
- No uncontrolled hypertension (i.e., diastolic blood pressure greater than 115 mmHg)
- No unstable angina
- No New York Heart Association class III or IV heart disease
- No congestive heart failure
- No coronary angioplasty within the past 6 months
- No myocardial infarction within the past 6 months
- No uncontrolled atrial or ventricular cardiac arrhythmia
Pulmonary
- No history of seasonal or recurrent asthma within the past 10 years
- No concurrent asthmatic symptoms (e.g., wheezing) related to a current respiratory
tract infection
Immunologic
- No prior positive allergy test (skin or radioallergosorbent test) for insect venoms
- No known allergy to E. coli-derived products
- No prior anaphylactic events manifested by disseminated urticaria, laryngeal edema,
and/or bronchospasm
- Drug allergies manifested solely by rash and/or urticaria allowed
- No recurrent urticaria (isolated episode of urticaria allowed)
- No other active uncontrolled infection (including one with current symptoms of
bronchoconstriction)
- No fever of 38.2° C or higher
- Fevers due to B symptoms allowed
Other
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No prior or concurrent CNS malignancy
- No poorly controlled diabetes
- No other significant nonmalignant disease
- No other malignancy except those in stable partial response or stable complete
response (no evidence of progressive disease for at least 8 weeks after therapy for
the malignancy)
PRIOR CONCURRENT THERAPY:
Biologic therapy
- See Hematopoietic in Patient Characteristics
- No prior stem cell factor
- No concurrent interleukin-11 for thrombocytopenia
Chemotherapy
- No concurrent chemotherapy for malignancy
Endocrine therapy
- Not specified
Radiotherapy
- Not specified
Surgery
- Not specified
Other
- No concurrent enrollment on any other protocol utilizing an investigational drug
- No concurrent beta adrenergic blocking agents