Phase III Intergroup Trial of Adjuvant Chemoradiation After Resection of Gastric or Gastroesophageal Adenocarcinoma
OBJECTIVES:
- Compare overall survival in patients with resected gastric adenocarcinoma treated with
epirubicin, cisplatin, and infusional fluorouracil (5-FU) vs 5-FU bolus and leucovorin
calcium before and after 5-FU plus radiotherapy.
- Compare disease-free survival and local and distant recurrence rates in these patients
treated with these regimens.
- Correlate the expression of putative prognostic markers (including TS, ERCC-1, MSI,
E-cadherin, EGFR, p27, COX-2, and c-erbB-2) with overall survival of patients treated
with these regimens.
- Correlate specific germline polymorphisms related to chemotherapy metabolism and
resistance (including UGT2B7 [epirubicin], GST [cisplatin], ERCCI [cisplatin], XRCC1
[cisplatin], TS [5-FU], DPD [5-FU], and EGFR polymorphisms) with treatment-related
toxicity and overall survival of these patients.
- Correlate serum levels of insulin-like growth factor-1 (IGF-1), IGF-2, and IGF-binding
protein 3 with overall survival of patients treated with these regimens.
OUTLINE: This is a randomized, multicenter study. Patients are stratified according to depth
of tumor penetration (T1 or T2 vs T3 vs T4), lymph node involvement (0 vs 1-3), and extent
of lymphadenectomy (D1 or D2 vs D0 or unknown). Patients are randomized to 1 of 2 treatment
arms.
- Arm I: Patients receive leucovorin calcium IV and fluorouracil (5-FU) IV on days 1-5 of
courses 1, 3, and 4. Courses repeat every 28 days. During course 2, patients undergo
radiotherapy 5 days a week and receive 5-FU IV continuously for 5 weeks. Patients rest
for 28-35 days between course 2 and 3.
- Arm II: Patients receive epirubicin IV over 3-15 minutes and cisplatin IV over 1 hour
on day 1 and 5-FU IV continuously on days 1-21 during course 1. Beginning 1 week later,
patients undergo radiotherapy 5 days a week and receive 5-FU IV continuously for 5
weeks. Patients rest for 28-35 days before beginning course 2 of chemotherapy. Patients
then receive epirubicin, cisplatin, and 5-FU as in course 1. Treatment repeats every 21
days for 2 courses.
Patients are followed every 3 months for 2 years, every 4 months for 2 years, and then
annually for 3 years.
PROJECTED ACCRUAL: A total of 824 patients will be accrued for this study.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Overall survival
3 years
No
Charles S. Fuchs, MD
Study Chair
Dana-Farber Cancer Institute
United States: Federal Government
CDR0000258787
NCT00052910
December 2002
June 2017
Name | Location |
---|---|
Fred Hutchinson Cancer Research Center | Seattle, Washington 98109 |
Memorial Sloan-Kettering Cancer Center | New York, New York 10021 |
University of Michigan Comprehensive Cancer Center | Ann Arbor, Michigan 48109-0752 |
Mayo Clinic Scottsdale | Scottsdale, Arizona 85259 |
Mayo Clinic Cancer Center | Rochester, Minnesota 55905 |
Cardinal Bernardin Cancer Center at Loyola University Medical Center | Maywood, Illinois 60153-5500 |
Walter Reed Army Medical Center | Washington, District of Columbia 20307-5000 |
University of Chicago Cancer Research Center | Chicago, Illinois 60637 |
CCOP - Upstate Carolina | Spartanburg, South Carolina 29303 |
CCOP - Wichita | Wichita, Kansas 67214-3882 |
Hurley Medical Center | Flint, Michigan 48503 |
CCOP - Kansas City | Kansas City, Missouri 64131 |
CCOP - Missouri Valley Cancer Consortium | Omaha, Nebraska 68131 |
CCOP - Christiana Care Health Services | Wilmington, Delaware 19899 |
CCOP - Mount Sinai Medical Center | Miami Beach, Florida 33140 |
Veterans Affairs Medical Center - Atlanta (Decatur) | Decatur, Georgia 30033 |
CCOP - Carle Cancer Center | Urbana, Illinois 61801 |
CCOP - Iowa Oncology Research Association | Des Moines, Iowa 50309-1016 |
Beth Israel Deaconess Medical Center | Boston, Massachusetts 02215 |
CCOP - Metro-Minnesota | Saint Louis Park, Minnesota 55416 |
Aurora Presbyterian Hospital | Aurora, Colorado 80012 |
Boulder Community Hospital | Boulder, Colorado 80301-9019 |
Penrose Cancer Center at Penrose Hospital | Colorado Springs, Colorado 80933 |
CCOP - Colorado Cancer Research Program | Denver, Colorado 80224-2522 |
Porter Adventist Hospital | Denver, Colorado 80210 |
Presbyterian - St. Luke's Medical Center | Denver, Colorado 80218 |
St. Joseph Hospital | Denver, Colorado 80218 |
Rose Medical Center | Denver, Colorado 80220 |
Swedish Medical Center | Englewood, Colorado 80110 |
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center | Grand Junction, Colorado 81502 |
Sky Ridge Medical Center | Lone Tree, Colorado 80124 |
Hope Cancer Care Center at Longmont United Hospital | Longmont, Colorado 80502 |
St. Mary - Corwin Regional Medical Center | Pueblo, Colorado 81004 |
North Suburban Medical Center | Thornton, Colorado 80229 |
Rush-Copley Cancer Care Center | Aurora, Illinois 60507 |
Joliet Oncology-Hematology Associates, Limited - West | Joliet, Illinois 60435 |
Carle Cancer Center at Carle Foundation Hospital | Urbana, Illinois 61801 |
Saint Anthony Memorial Health Centers | Michigan City, Indiana 46360 |
Mercy Medical Center - Sioux City | Sioux City, Iowa 51104 |
Siouxland Hematology-Oncology Associates, LLP | Sioux City, Iowa 51101 |
St. Luke's Regional Medical Center | Sioux City, Iowa 51104 |
Tufts-NEMC Cancer Center | Boston, Massachusetts 02111 |
CCOP - Michigan Cancer Research Consortium | Ann Arbor, Michigan 48106 |
Saint Joseph Mercy Cancer Center | Ann Arbor, Michigan 48106-0995 |
Oakwood Cancer Center at Oakwood Hospital and Medical Center | Dearborn, Michigan 48123-2500 |
Genesys Hurley Cancer Institute | Flint, Michigan 48503 |
Van Elslander Cancer Center at St. John Hospital and Medical Center | Grosse Pointe Woods, Michigan 48236 |
Bronson Methodist Hospital | Kalamazoo, Michigan 49007 |
West Michigan Cancer Center | Kalamazoo, Michigan 49007-3731 |
Borgess Medical Center | Kalamazooaa, Michigan 49001 |
Sparrow Regional Cancer Center | Lansing, Michigan 48912-1811 |
St. John Macomb Hospital | Warren, Michigan 48093 |
Fairview Ridges Hospital | Burnsville, Minnesota 55337 |
Mercy and Unity Cancer Center at Mercy Hospital | Coon Rapids, Minnesota 55433 |
Duluth Clinic Cancer Center - Duluth | Duluth, Minnesota 55805-1983 |
CCOP - Duluth | Duluth, Minnesota 55805 |
Miller - Dwan Medical Center | Duluth, Minnesota 55805 |
Fairview Southdale Hospital | Edina, Minnesota 55435 |
Mercy and Unity Cancer Center at Unity Hospital | Fridley, Minnesota 55432 |
Hutchinson Area Health Care | Hutchinson, Minnesota 55350 |
Meeker County Memorial Hospital | Lichfield, Minnesota 55355 |
Minnesota Oncology Hematology, PA - Maplewood | Maplewood, Minnesota 55109 |
HealthEast Cancer Care at St. John's Hospital | Maplewood, Minnesota 55109 |
Hennepin County Medical Center - Minneapolis | Minneapolis, Minnesota 55415 |
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | Minneapolis, Minnesota 55407 |
Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center | Robbinsdale, Minnesota 55422-2900 |
St. Francis Cancer Center at St. Francis Medical Center | Shakopee, Minnesota 55379 |
HealthEast Cancer Care at St. Joseph's Hospital | St Paul, Minnesota 55102 |
Park Nicollet Cancer Center | St. Louis Park, Minnesota 55416 |
Regions Hospital Cancer Care Center | St. Paul, Minnesota 55101 |
United Hospital | St. Paul, Minnesota 55102 |
Ridgeview Medical Center | Waconia, Minnesota 55387 |
Minnesota Oncology Hematology, PA - Woodbury | Woodbury, Minnesota 55125 |
HealthEast Cancer Care at Woodwinds Health Campus | Woodbury, Minnesota 55125 |
Aultman Cancer Center at Aultman Hospital | Canton, Ohio 44710-1799 |
MetroHealth Cancer Care Center at MetroHealth Medical Center | Cleveland, Ohio 44109 |
St. Rita's Medical Center | Lima, Ohio 45801 |
Penn State Cancer Institute at Milton S. Hershey Medical Center | Hershey, Pennsylvania 17033-0850 |
Abramson Cancer Center of the University of Pennsylvania | Philadelphia, Pennsylvania 19104-4283 |
Geisinger Medical Group - Scenery Park | State College, Pennsylvania 16801 |
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center | Wilkes-Barre, Pennsylvania 18711 |
Sanford Cancer Center at Sanford USD Medical Center | Sioux Falls, South Dakota 57117-5039 |
Medical X-Ray Center, PC | Sioux Falls, South Dakota 57105 |
Avera Cancer Institute | Sioux Falls, South Dakota 57105 |
Marshfield Clinic - Marshfield Center | Marshfield, Wisconsin 54449 |
Medical College of Wisconsin Cancer Center | Milwaukee, Wisconsin 53226 |
Marshfield Clinic - Indianhead Center | Rice Lake, Wisconsin 54868 |
CCOP - Ochsner | New Orleans, Louisiana 70121 |
Providence Saint Joseph Medical Center - Burbank | Burbank, California 91505 |
CCOP - Bay Area Tumor Institute | Oakland, California 94609-3305 |
Memorial Hospital of South Bend | South Bend, Indiana 46601 |
Cape Cod Hospital | Hyannis, Massachusetts 02601 |
CCOP - Cancer Research for the Ozarks | Springfield, Missouri 65807 |
CCOP - Montana Cancer Consortium | Billings, Montana 59101 |
John F. Kennedy Medical Center | Edison, New Jersey 08818 |
CCOP - Columbus | Columbus, Ohio 43206 |
Veterans Affairs Medical Center - Dayton | Dayton, Ohio 45428 |
CCOP - Dayton | Kettering, Ohio 45429 |
Albert Einstein Cancer Center | Philadelphia, Pennsylvania 19141 |
Mercy Hospital Cancer Center - Scranton | Scranton, Pennsylvania 18501 |
Grand View Hospital | Sellersville, Pennsylvania 18960 |
CCOP - Greenville | Greenville, South Carolina 29615 |
LDS Hospital | Salt Lake City, Utah 84143 |
CCOP - Northern Indiana CR Consortium | South Bend, Indiana 46601 |
Saint Joseph Regional Medical Center | South Bend, Indiana 46617 |
Holden Comprehensive Cancer Center at University of Iowa | Iowa City, Iowa 52242-1002 |
CCOP - Grand Rapids | Grand Rapids, Michigan 49503 |
Ellis Fischel Cancer Center at University of Missouri - Columbia | Columbia, Missouri 65203 |
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Chapel Hill, North Carolina 27599-7570 |
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia, Pennsylvania 19107 |
CCOP - Scott and White Hospital | Temple, Texas 76508 |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore, Maryland 21231-2410 |
MBCCOP - LSU Health Sciences Center | New Orleans, Louisiana 70112 |
Brooke Army Medical Center | Fort Sam Houston, Texas 78234-6200 |
Kaiser Permanente Medical Center - Vallejo | Vallejo, California 94589 |
Kent County Memorial Hospital | Warwick, Rhode Island 02886 |
Utah Valley Regional Medical Center - Provo | Provo, Utah 84604 |
Veterans Affairs Medical Center - Buffalo | Buffalo, New York 14215 |
Rebecca and John Moores UCSD Cancer Center | La Jolla, California 92093-0658 |
Wesley Medical Center | Wichita, Kansas 67214 |
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute | Boston, Massachusetts 02115 |
City of Hope Comprehensive Cancer Center | Duarte, California 91010 |
West Suburban Center for Cancer Care | River Forest, Illinois 60305 |
John Stoddard Cancer Center at Iowa Methodist Medical Center | Des Moines, Iowa 50309 |
Kaiser Permanente Medical Center - San Francisco Geary Campus | San Francisco, California 94115 |
Medical Center of Central Georgia | Macon, Georgia 31201 |
St. Vincent Mercy Medical Center | Toledo, Ohio 43608 |
Arizona Cancer Center at University of Arizona Health Sciences Center | Tucson, Arizona 85724 |
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences | Little Rock, Arkansas 72205 |
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus | Seattle, Washington 98104 |
Thompson Cancer Survival Center | Knoxville, Tennessee 37916 |
Blumenthal Cancer Center at Carolinas Medical Center | Charlotte, North Carolina 28232-2861 |
Overlook Hospital | Summit, New Jersey 07902-0220 |
Hulston Cancer Center at Cox Medical Center South | Springfield, Missouri 65807 |
St. John's Regional Health Center | Springfield, Missouri 65804 |
Carol G. Simon Cancer Center at Morristown Memorial Hospital | Morristown, New Jersey 07962 |
SUNY Downstate Medical Center | Brooklyn, New York 11203 |
McDowell Cancer Center at Akron General Medical Center | Akron, Ohio 44307 |
CCOP - Toledo Community Hospital | Toledo, Ohio 43623-3456 |
Wilford Hall Medical Center | Lackland Air Force Base, Texas 78236-5300 |
Waukesha Memorial Hospital Regional Cancer Center | Waukesha, Wisconsin 53188 |
Kaiser Permanente Medical Center - Oakland | Sacramento, California 95825 |
Broward General Medical Center Cancer Center | Ft. Lauderdale, Florida 33316 |
Sacred Heart Cancer Center at Sacred Heart Hospital | Pensacola, Florida 32504 |
Winship Cancer Institute of Emory University | Atlanta, Georgia 30322 |
Advocate Christ Medical Center | Oak Lawn, Illinois 60453 |
Via Christi Cancer Center at Via Christi Regional Medical Center | Wichita, Kansas 67214 |
Ochsner Cancer Institute at Ochsner Clinic Foundation | New Orleans, Louisiana 70121 |
SUNY Upstate Medical University Hospital | Syracuse, New York 13210 |
Mission Hospitals - Memorial Campus | Asheville, North Carolina 28801 |
Presbyterian Cancer Center at Presbyterian Hospital | Charlotte, North Carolina 28233-3549 |
Wake Forest University Comprehensive Cancer Center | Winston-Salem, North Carolina 27157-1096 |
Medical University of Ohio Cancer Center | Toledo, Ohio 43614 |
Toledo Hospital | Toledo, Ohio 43606 |
Edwards Comprehensive Cancer Center at Cabell Huntington Hospital | Huntington, West Virginia 25701 |
St. Vincent Hospital Regional Cancer Center | Green Bay, Wisconsin 54307-3508 |
Lahey Clinic Medical Center - Burlington | Burlington, Massachusetts 01805 |
James P. Wilmot Cancer Center at University of Rochester Medical Center | Rochester, New York 14642 |
McCreery Cancer Center at Ottumwa Regional | Ottumwa, Iowa 52501 |
Green Bay Oncology, Limited - Escanaba | Escanaba, Michigan 49431 |
Dickinson County Healthcare System | Iron Mountain, Michigan 49801 |
Our Lady of Mercy Medical Center Comprehensive Cancer Center | Bronx, New York 10466 |
CCOP - Hematology-Oncology Associates of Central New York | East Syracuse, New York 13057 |
Lewistown Hospital | Lewistown, Pennsylvania 17044 |
Mount Nittany Medical Center | State College, Pennsylvania 16803 |
St. Mary's Hospital Medical Center - Green Bay | Green Bay, Wisconsin 54303 |
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center | Green Bay, Wisconsin 54301-3526 |
Green Bay Oncology, Limited at St. Mary's Hospital | Green Bay, Wisconsin 54303 |
Bay Area Cancer Care Center at Bay Area Medical Center | Marinette, Wisconsin 54143 |
Green Bay Oncology, Limited - Oconto Falls | Oconto Falls, Wisconsin 54154 |
Green Bay Oncology, Limited - Sturgeon Bay | Sturgeon Bay, Wisconsin 54235 |
Hematology Oncology Associates of the Quad Cities | Bettendorf, Iowa 52722 |
North Colorado Medical Center | Greeley, Colorado 80631 |
McKee Medical Center | Loveland, Colorado 80539 |
Baptist Cancer Institute - Jacksonville | Jacksonville, Florida 32207 |
Southwest Medical Center | Liberal, Kansas 67901 |
Battle Creek Health System Cancer Care Center | Battle Creek, Michigan 49017 |
William Beaumont Hospital - Royal Oak Campus | Royal Oak, Michigan 48073 |
Munson Medical Center | Traverse City, Michigan 49684 |
Northern Rockies Radiation Oncology Center | Billings, Montana 59101 |
Hematology-Oncology Centers of the Northern Rockies - Billings | Billings, Montana 59101 |
Big Sky Oncology | Great Falls, Montana 59405 |
Kalispell Regional Medical Center | Kalispell, Montana 59901 |
Glacier Oncology, PLLC | Kalispell, Montana 59901 |
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center | Missoula, Montana 59802 |
Montana Cancer Specialists at Montana Cancer Center | Missoula, Montana 59802 |
Community Medical Center | Missoula, Montana 59801 |
Wayne Memorial Hospital, Incorporated | Goldsboro, North Carolina 27534 |
Adena Regional Medical Center | Chillicothe, Ohio 54601 |
Doctors Hospital at Ohio Health | Columbus, Ohio 43228 |
Riverside Methodist Hospital Cancer Care | Columbus, Ohio 43214 |
Grady Memorial Hospital | Delaware, Ohio 43015 |
Fairfield Medical Center | Lancaster, Ohio 43130 |
Strecker Cancer Center at Marietta Memorial Hospital | Marietta, Ohio 45750 |
Licking Memorial Cancer Care Program at Licking Memorial Hospital | Newark, Ohio 43055 |
Community Hospital of Springfield and Clark County | Springfield, Ohio 45505 |
Genesis - Good Samaritan Hospital | Zanesville, Ohio 43701 |
American Fork Hospital | American Fork, Utah 84003 |
Utah Cancer Specialists at UCS Cancer Center | Salt Lake City, Utah 84106 |
Olympic Hematology and Oncology | Bremerton, Washington 98310 |
University Cancer Center at University of Washington Medical Center | Seattle, Washington 98195 |
Harborview Medical Center | Seattle, Washington 98104 |
Group Health Central Hospital | Seattle, Washington 98104 |
Cancer Care Northwest - Spokane South | Spokane, Washington 99202 |
Veterans Affairs Medical Center - Hines | Hines, Illinois 60141 |
Greenebaum Cancer Center at University of Maryland Medical Center | Baltimore, Maryland 21201 |
Memorial Cancer Institute at Memorial Regional Hospital | Hollywood, Florida 33021 |
Kaiser Permanente Medical Center - Santa Clara Kiely Campus | Santa Clara, California 95051-5386 |
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center | Washington, District of Columbia 20007 |
Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center | Savannah, Georgia 31403-3089 |
Mountain States Tumor Institute at St. Luke's Regional Medical Center | Boise, Idaho 83712-6297 |
University of Illinois Cancer Center | Chicago, Illinois 60612-7243 |
Swedish-American Regional Cancer Center | Rockford, Illinois 61104-2315 |
Indiana University Melvin and Bren Simon Cancer Center | Indianapolis, Indiana 46202-5289 |
Butterworth Hospital at Spectrum Health | Grand Rapids, Michigan 49503-2560 |
Masonic Cancer Center at University of Minnesota | Minneapolis, Minnesota 55455 |
CCOP - Nevada Cancer Research Foundation | Las Vegas, Nevada 89109-2306 |
St. Barnabas Medical Center Cancer Center | Livingston, New Jersey 07039 |
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School | New Brunswick, New Jersey 08903 |
Dakota Cancer Institute at Dakota Clinic - South University | Fargo, North Dakota 58103-4940 |
Oklahoma University Cancer Institute | Oklahoma City, Oklahoma 73104 |
Geisinger Cancer Institute at Geisinger Health | Danville, Pennsylvania 17822-0001 |
Virginia Commonwealth University Massey Cancer Center | Richmond, Virginia 23298-0037 |
Madigan Army Medical Center - Tacoma | Tacoma, Washington 98431 |
West Virginia University Health Sciences Center - Charleston | Charleston, West Virginia 25302 |
Kaiser Permanente Medical Center - Sacramento | Sacramento, California 95825 |
Methodist Estabrook Cancer Center | Omaha, Nebraska 68114-4199 |
Huntsman Cancer Institute at University of Utah | Salt Lake City, Utah 84112 |
Robert H. Lurie Comprehensive Cancer Center at Northwestern University | Chicago, Illinois 60611 |
Decatur Memorial Hospital Cancer Care Institute | Decatur, Illinois 62526 |
Helen and Harry Gray Cancer Center at Hartford Hospital | Hartford, Connecticut 06102-5037 |
Elkhart General Hospital | Elkhart, Indiana 46515 |
Howard Community Hospital | Kokomo, Indiana 46904 |
South Bend Clinic | South Bend, Indiana 46617 |
Lakeland Regional Cancer Care Center - St. Joseph | St. Joseph, Michigan 49085 |
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton | Marlton, New Jersey 08053 |
Fox Chase Virtua Health Cancer Program at Virtua West Jersey | Voorhees, New Jersey 08043 |
Mount Carmel Health - West Hospital | Columbus, Ohio 43222 |
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center | Columbus, Ohio 43210-1240 |
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest | Allentown, Pennsylvania 18105 |
Fox Chase Cancer Center - Philadelphia | Philadelphia, Pennsylvania 19111-2497 |
Veterans Affairs Medical Center - Chicago Westside Hospital | Chicago, Illinois 60612 |
Hematology Oncology Associates - Skokie | Skokie, Illinois 60076 |
University Medical Center of Southern Nevada | Las Vegas, Nevada 89102 |
Joan Karnell Cancer Center at Pennsylvania Hospital | Philadelphia, Pennsylvania 19107 |
UPMC Cancer Centers | Pittsburgh, Pennsylvania 15232 |
Jennersville Regional Hospital | West Grove, Pennsylvania 19390-9499 |
Eden Medical Center | Castro Valley, California 94546 |
Kaiser Permanente - Fremont | Fremont, California 94538 |
Kaiser Permanente Medical Center - Hayward | Hayward, California 94545 |
Alta Bates Summit Medical Center - Summit Campus | Oakland, California 94609 |
Valley Care Medical Center | Pleasanton, California 94588 |
Kaiser Permanente Medical Center - Redwood City | Redwood City, California 94063 |
Kaiser Permanente Medical Center - Richmond | Richmond, California 94801 |
Kaiser Permanente Medical Center - Roseville | Roseville, California 95661 |
South Sacramento Kaiser-Permanente Medical Center | Sacramento, California 95823 |
Kaiser Permanente Medical Center - Santa Teresa | San Jose, California 95119 |
Kaiser Foundation Hospital - San Rafael | San Rafael, California 94903 |
Kaiser Permanente Medical Center - Santa Rosa | Santa Rosa, California 95403 |
Kaiser Permanente Medical Center - South San Francisco | South San Francisco, California 94080 |
Kaiser Permanente Medical Facility - Stockton | Stockton, California 95210 |
Kaiser Permanente Medical Center - Walnut Creek | Walnut Creek, California 94596 |
Ella Milbank Foshay Cancer Center at Jupiter Medical Center | Jupiter, Florida 33458 |
Hematology and Oncology Associates | Chicago, Illinois 60611 |
Ingalls Cancer Care Center at Ingalls Memorial Hospital | Harvey, Illinois 60426 |
Midwest Center for Hematology/Oncology | Joliet, Illinois 60432 |
North Shore Oncology and Hematology Associates, Limited - Libertyville | Libertyville, Illinois 60048 |
Edward Hospital Cancer Center | Naperville, Illinois 60540 |
Hematology Oncology Consultants - Naperville | Naperville, Illinois 60540 |
St. Francis Hospital and Health Centers - Beech Grove Campus | Beech Grove, Indiana 46107 |
Fort Wayne Medical Oncology and Hematology | Fort Wayne, Indiana 46815 |
Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte, Indiana 46350 |
St. Luke's Hospital | Cedar Rapids, Iowa 52402 |
Mercy Regional Cancer Center at Mercy Medical Center | Cedar Rapids, Iowa 52403 |
John Stoddard Cancer Center at Iowa Lutheran Hospital | Des Moines, Iowa 50316-2301 |
Mercy Capitol Hospital | Des Moines, Iowa 50307 |
Medical Oncology and Hematology Associates at John Stoddard Cancer Center | Des Moines, Iowa 50309 |
Medical Oncology and Hematology Associates at Mercy Cancer Center | Des Moines, Iowa 50314 |
Mercy Cancer Center at Mercy Medical Center - Des Moines | Des Moines, Iowa 50314 |
Medical Oncology and Hematology Associates - West Des Moines | West Des Moines, Iowa 50266 |
Cancer Center of Kansas, PA - Dodge City | Dodge City, Kansas 67801 |
St. Francis Comprehensive Cancer Center | Topeka, Kansas 66606 |
Pennington Cancer Center at Baton Rouge General | Baton Rouge, Louisiana 70806 |
Mary Bird Perkins Cancer Center - Baton Rouge | Baton Rouge, Louisiana 70809 |
Terrebonne General Medical Center | Houma, Louisiana 70360 |
Medical Center of Louisiana - New Orleans | New Orleans, Louisiana 70112 |
Hickman Cancer Center at Bixby Medical Center | Adrian, Michigan 49221 |
Bay Regional Medical Center | Bay City, Michigan 48708 |
Mecosta County Medical Center | Big Rapids, Michigan 49307 |
Community Cancer Center of Monroe | Monroe, Michigan 48162 |
Alexandria, Minnesota 56308 | |
Coborn Cancer Center | Saint Cloud, Minnesota 56303 |
CentraCare Clinic - River Campus | St. Cloud, Minnesota 56303 |
Immanuel Medical Center | Omaha, Nebraska 68122 |
Creighton University Medical Center | Omaha, Nebraska 68131-2197 |
Cancer Institute of New Jersey at Cooper - Voorhees | Voorhees, New Jersey 08043 |
Bismarck Cancer Center | Bismarck, North Dakota 58501 |
Wood County Oncology Center | Bowling Green, Ohio 43402 |
Grandview Hospital | Dayton, Ohio 45405 |
Good Samaritan Hospital | Dayton, Ohio 45406 |
Blanchard Valley Medical Associates | Findlay, Ohio 45840 |
Charles F. Kettering Memorial Hospital | Kettering, Ohio 45429 |
Lima Memorial Hospital | Lima, Ohio 45804 |
St. Luke's Hospital | Maumee, Ohio 43537 |
Northwest Ohio Oncology Center | Maumee, Ohio 43537 |
Middletown Regional Hospital | Middletown, Ohio 45044 |
Toledo Clinic - Oregon | Oregon, Ohio 43616 |
St. Charles Mercy Hospital | Oregon, Ohio 43616 |
North Coast Cancer Care, Incorporated | Sandusky, Ohio 44870 |
Mercy Medical Center | Springfield, Ohio 45504 |
Mercy Hospital of Tiffin | Tiffin, Ohio 44883 |
Toledo Clinic, Incorporated - Main Clinic | Toledo, Ohio 43623 |
UVMC Cancer Care Center at Upper Valley Medical Center | Troy, Ohio 45373-1300 |
Fulton County Health Center | Wauseon, Ohio 43567 |
Ruth G. McMillan Cancer Center at Greene Memorial Hospital | Xenia, Ohio 45385 |
Kaiser Permanente Health Care - Portland | Portland, Oregon 97232 |
Bryn Mawr Hospital | Bryn Mawr, Pennsylvania 19010 |
St. Mary Regional Cancer Center | Langhorne, Pennsylvania 19047 |
Lankenau Cancer Center at Lankenau Hospital | Wynnewood, Pennsylvania 19096 |
Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center | Kingsport, Tennessee 37662 |
Doctor's Hospital of Laredo | Laredo, Texas 78041 |
Dixie Regional Medical Center - East Campus | Saint George, Utah 84770 |
Danville Regional Medical Center | Danville, Virginia 24541 |
Virginia Oncology Associates - Hampton | Hampton, Virginia 23666 |
Minor and James Medical, PLLC | Seattle, Washington 98104 |
Polyclinic First Hill | Seattle, Washington 98122 |
San Francisco General Hospital Medical Center | San Francisco, California 94110 |
Massachusetts General Hospital | Boston, Massachusetts 02114-2617 |
St. Anthony Central Hospital | Denver, Colorado 80204-1335 |
Exempla Lutheran Medical Center | Wheat Ridge, Colorado 80033 |
St. Anthony's Memorial Hospital | Effingham, Illinois 62401 |
Morton Hospital & Medical Center | Taunton, Massachusetts 02780 |
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center | Ft. Smith, Arkansas 72903 |
Highland General Hospital | Oakland, California 94602 |
Creticos Cancer Center at Advocate Illinois Masonic Medical Center | Chicago, Illinois 60657 |
Cancer Center at Ball Memorial Hospital | Muncie, Indiana 47303 |
Regional Cancer Center at Singing River Hospital | Pascagoula, Mississippi 39581 |
Missouri Baptist Cancer Center | St. Louis, Missouri 63131 |
Cancer Resource Center - Lincoln | Lincoln, Nebraska 68510 |
Altru Cancer Center at Altru Hospital | Grand Forks, North Dakota 58201 |
Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford | Salem, Ohio 44460 |
Cancer Treatment Center | Wooster, Ohio 44691 |
Kaiser Permanente - Deer Valley | Antioch, California 94531 |
Praxair Cancer Center at Danbury Hospital | Danbury, Connecticut 06810 |
Tunnell Cancer Center at Beebe Medical Center | Lewes, Delaware 19958 |
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital | Fort Lauderdale, Florida 33308 |
West Florida Cancer Institute at West Florida Hospital - Pensacola | Pensacola, Florida 32514 |
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler | Savannah, Georgia 31405 |
Hematology Oncology Associates of Illinois - Berwyn | Berwyn, Illinois 60402 |
La Grange Oncology Associates - Geneva | Naperville, Illinois 60563 |
Cancer Care and Hematology Specialists of Chicagoland - Niles | Niles, Illinois 60714 |
William N. Wishard Memorial Hospital | Indianapolis, Indiana 46202 |
Medical Consultants, PC at Ball Memorial Cancer Center | Muncie, Indiana 47303 |
Reid Hospital & Health Care Services | Richmond, Indiana 47374 |
McFarland Clinic, PC | Ames, Iowa 50010 |
Covenant Cancer Treatment Center | Waterloo, Iowa 50702 |
Cancer Center of Kansas, PA - Chanute | Chanute, Kansas 66720 |
Cancer Center of Kansas, PA - El Dorado | El Dorado, Kansas 67042 |
Cancer Center of Kansas - Fort Scott | Fort Scott, Kansas 66701 |
Cancer Center of Kansas-Independence | Independence, Kansas 67301 |
Cancer Center of Kansas, PA - Kingman | Kingman, Kansas 67068 |
Lawrence Memorial Hospital | Lawrence, Kansas 66044 |
Cancer Center of Kansas, PA - Newton | Newton, Kansas 67114 |
Menorah Medical Center | Overland Park, Kansas 66209 |
Cancer Center of Kansas, PA - Parsons | Parsons, Kansas 67357 |
Cancer Center of Kansas, PA - Pratt | Pratt, Kansas 67124 |
Tammy Walker Cancer Center at Salina Regional Health Center | Salina, Kansas 67401 |
Cancer Center of Kansas, PA - Salina | Salina, Kansas 67401 |
Shawnee Mission Medical Center | Shawnee Mission, Kansas 66204 |
Cotton-O'Neil Cancer Center | Topeka, Kansas 66606 |
Cancer Center of Kansas, PA - Wellington | Wellington, Kansas 67152 |
Cancer Center of Kansas, PA - Wichita | Wichita, Kansas 67214 |
Associates in Womens Health, PA - North Review | Wichita, Kansas 67208 |
Cancer Center of Kansas, PA - Medical Arts Tower | Wichita, Kansas 67208 |
Cancer Center of Kansas, PA - Winfield | Winfield, Kansas 67156 |
Ochsner Health Center - Bluebonnet | Baton Rouge, Louisiana 70809 |
Union Hospital Cancer Program at Union Hospital | Elkton MD, Maryland 21921 |
Foote Memorial Hospital | Jackson, Michigan 49201 |
Haematology-Oncology Associates of Ohio and Michigan, PC | Lambertville, Michigan 48144 |
St. Mary Mercy Hospital | Livonia, Michigan 48154 |
Mercy Memorial Hospital - Monroe | Monroe, Michigan 48162 |
St. Joseph Mercy Oakland | Pontiac, Michigan 48341-2985 |
Mercy Regional Cancer Center at Mercy Hospital | Port Huron, Michigan 48060 |
Seton Cancer Institute at Saint Mary's - Saginaw | Saginaw, Michigan 48601 |
Willmar Cancer Center at Rice Memorial Hospital | Willmar, Minnesota 56201 |
Truman Medical Center - Hospital Hill | Kansas City, Missouri 64108 |
St. Joseph Medical Center | Kansas City, Missouri 64114 |
North Kansas City Hospital | Kansas City, Missouri 64116 |
Saint Luke's Cancer Institute at Saint Luke's Hospital | Kansas City, Missouri 64111 |
Research Medical Center | Kansas City, Missouri 64132 |
Liberty Hospital | Liberty, Missouri 64068 |
Heartland Regional Medical Center | Saint Joseph, Missouri 64506 |
Arch Medical Services, Incorporated at Center for Cancer Care and Research | Saint Louis, Missouri 63141 |
Billings Clinic - Downtown | Billings, Montana 59107-7000 |
St. James Healthcare Cancer Care | Butte, Montana 59701 |
Great Falls Clinic - Main Facility | Great Falls, Montana 59405 |
Sletten Cancer Institute at Benefis Healthcare | Great Falls, Montana 59405 |
Northern Montana Hospital | Havre, Montana 59501 |
Kalispell Medical Oncology at KRMC | Kalispell, Montana 59901 |
Alegant Health Cancer Center at Bergan Mercy Medical Center | Omaha, Nebraska 68124 |
Leo W. Jenkins Cancer Center at ECU Medical School | Greenville, North Carolina 27834 |
Summa Center for Cancer Care at Akron City Hospital | Akron, Ohio 44309-2090 |
Mary Rutan Hospital | Bellefontaine, Ohio 43311 |
North Coast Cancer Care - Clyde | Clyde, Ohio 43410 |
Grant Medical Center Cancer Care | Columbus, Ohio 43215 |
Hematology Oncology Center | Elyria, Ohio 44035 |
Flower Hospital Cancer Center | Sylvania, Ohio 43560 |
St. Anne Mercy Hospital | Toledo, Ohio 43623 |
Mount Carmel St. Ann's Cancer Center | Westerville, Ohio 43081 |
Clinton Memorial Hospital | Wilmington, Ohio 45177 |
Cleo Craig Cancer Research Clinic | Lawton, Oklahoma 73505 |
Cancer Care Associates - Mercy Campus | Oklahoma City, Oklahoma 73120 |
Salem Hospital Regional Cancer Care Services | Salem, Oregon 97309-5014 |
St. Luke's Cancer Network at St. Luke's Hospital | Bethlehem, Pennsylvania 18015 |
Guthrie Cancer Center at Guthrie Clinic Sayre | Sayre, Pennsylvania 18840 |
Hematology and Oncology Associates of Northeastern Pennsylvania | Scranton, Pennsylvania 18510 |
Sandra L. Maxwell Cancer Center | Cedar City, Utah 84720 |
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center | Murray, Utah 84157 |
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center | Ogden, Utah 84403 |
Fredericksburg Oncology, Incorporated | Fredericksburg, Virginia 22401 |
Southwest Virginia Regional Cancer Center at Wellmonth Health | Norton, Virginia 24273 |
St. Joseph Cancer Center | Bellingham, Washington 98225 |
Columbia Basin Hematology | Kennewick, Washington 99336 |
Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital | Parkersburg, West Virginia 26102 |
Marshfield Clinic Cancer Care at Regional Cancer Center | Eau Claire, Wisconsin 54701 |
Marshfield Clinic - Lakeland Center | Minocqua, Wisconsin 54548 |
Ministry Medical Group at Saint Mary's Hospital | Rhinelander, Wisconsin 54501 |
Marshfield Clinic - Weston Center | Weston, Wisconsin 54476 |
Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids, Wisconsin 54494 |
FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center | Pinehurst, North Carolina 28374 |
Mid Dakota Clinic, PC | Bismarck, North Dakota 58501 |
Regional Cancer Center at Memorial Medical Center | Springfield, Illinois 62781-0001 |
Community Hospital | Munster, Indiana 46321 |
Memorial Hospital of Rhode Island | Pawtucket, Rhode Island 02860 |
Phoebe Cancer Center at Phoebe Putney Memorial Hospital | Albany, Georgia 31702 |
Lowell General Hospital | Lowell, Massachusetts 01854 |
Good Samaritan Cancer Center at Good Samaritan Hospital | Kearney, Nebraska 68848-1990 |
Elliot Regional Cancer Center at Elliot Hospital | Manchester, New Hampshire 03103 |
Rutherford Hospital | Rutherfordton, North Carolina 28139 |
Easton Regional Cancer Center at Easton Hospital | Easton, Pennsylvania 18042 |
Mercy Cancer Institute at Mercy Hospital | Pittsburgh, Pennsylvania 15219 |
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center | Spartanburg, South Carolina 29303 |
Regional Cancer Center at Oconomowoc Memorial Hospital | Oconomowoc, Wisconsin 53066 |
Dana-Farber/Brigham and Women's Cancer Center | Boston, Massachusetts 02115 |
Kinston Medical Specialists | Kinston, North Carolina 28501 |
Glendale Memorial Hospital Comprehensive Cancer Center | Glendale, California 91204 |
Resurrection Medical Center | Chicago, Illinois 60631 |
Nalitt Cancer Institute at Staten Island University Hospital | Staten Island, New York 10305 |
La Grange Memorial Hospital | La Grange, Illinois 60525 |
Cedar Valley Medical Specialists, PC - West Ridgeway Avenue | Waterloo, Iowa 50702 |
Lacks Cancer Center at Saint Mary's Health Care | Grand Rapids, Michigan 49503 |
Metro Health Hospital | Grand Rapids, Michigan 49506 |
Great Falls, Montana 59405 | |
Guardian Oncology and Center for Wellness | Missoula, Montana 59804 |
Roper St. Francis Cancer Center at Roper Hospital | Charleston, South Carolina 29401 |
Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare | Vineland, New Jersey 08360 |
Oncology Hematology Associates of Northern Pennsylvania, PC at Hahne Regional Cancer Center | Dubois, Pennsylvania 15801 |
Associates in Oncology and Hematology | Rockville, Maryland 20850 |
Doctors Medical Center - San Pablo Campus | San Pablo, California 94806 |
Boston University Cancer Research Center | Boston, Massachusetts 02118 |
St. Vincent Healthcare Cancer Care Services | Billings, Montana 59101 |
Center for Cancer Care and Research at Watson Clinic, LLP | Lakeland, Florida 33805 |
Berkshire Hematology Oncology, PC | Pittsfield, Massachusetts 01201 |
Oncology Care Associates, PLLC | Saint Joseph, Michigan 49085 |
Independence Regional Health Center | Independence, Missouri 64050 |
Parvin Radiation Oncology | Kansas City, Missouri 64116 |
Lynchburg Hematology-Oncology Clinic | Lynchburg, Virginia 24501 |
Providence Cancer Center at Providence Hospital | Mobile, Alabama 36608 |
East Bay Radiation Oncology Center | Castro Valley, California 94546 |
Contra Costa Regional Medical Center | Martinez, California 94553-3156 |
Memorial Medical Center | Modesto, California 95355 |
El Camino Hospital Cancer Center | Mountain View, California 94040 |
Larry G Strieff MD Medical Corporation | Oakland, California 94609 |
Tom K Lee, Incorporated | Oakland, California 94609 |
Bay Area Breast Surgeons, Incorporated | Oakland, California 94609 |
Valley Medical Oncology Consultants - Pleasanton | Pleasanton, California 94588 |
Elmhurst Memorial Hospital | Elmhurst, Illinois 60126 |
Iowa Blood and Cancer Care | Cedar Rapids, Iowa 52402 |
Caritas St. Elizabeth's Medical Center | Brighton, Massachusetts 02135-2997 |
Mercy General Health Partners | Muskegon, Michigan 49443 |
Hattiesburg Clinic, PA at Forrest General | Hattiesburg, Mississippi 39401 |
Christian Hospital Northeast Cancer Care Center | Saint Louis, Missouri 63136 |
Riddle Memorial Hospital Cancer Center | Media, Pennsylvania 19063 |
Cancer Center of Paoli Memorial Hospital | Paoli, Pennsylvania 19301-1792 |
CCOP - Main Line Health | Wynnewood, Pennsylvania 19096 |
AnMed Cancer Center | Anderson, South Carolina 29621 |
Dale and Frances Hughes Cancer Center at Pocono Medical Center | East Stroudsburg, Pennsylvania 18301 |
Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields | Olympia Fields, Illinois 60461 |
Medcenter One Hospital Cancer Care Center | Bismarck, North Dakota 58501 |
St. Alexius Medical Center Cancer Center | Bismarck, North Dakota 58502 |
Cleveland Clinic Florida - Weston | Weston, Florida 33331 |
South Shore Hospital | South Weymouth, Massachusetts 02190 |
Ben E. Owens Cancer Treatment Center at St. Bernard's Medical Center | Jonesboro, Arkansas 72401-9320 |
Regional Medical Center | Anniston, Alabama 36202 |
Valley Medical Oncology Consultants - Castro Valley | Castro Valley, California 94546 |
Valley Medical Oncology | Fremont, California 94538 |
Memorial Hospital Cancer Center - Colorado Springs | Colorado Springs, Colorado 80909 |
Ochsner Health Center - Covington | Covington, Louisiana 70433 |
Hudner Oncology Center at Saint Anne's Hospital - Fall River | Fall River, Massachusetts 02721 |
Addison Gilbert Hospital | Gloucester, Massachusetts 01930 |
Hematology & Oncology Clinic | Hattiesburg, Mississippi 39402 |
Frankford Hospital Cancer Center - Torresdale Campus | Philadelphia, Pennsylvania 19114 |
Shore Regional Cancer Center at Memorial Hospital - Easton | Easton, Maryland 21601 |
Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus | Boca Raton, Florida 33486 |
Community Hospital of the Monterey Peninsula Comprehensive Cancer Center | Monterey, California 93940 |
Camino Medical Group - Treatment Center | Mountain View, California 94040 |
Associates in Oncology and Hematology - Medical Center Drive | Rockville, Maryland 20878 |
CentraState Medical Center | Freehold, New Jersey 07728 |
Kings County Hospital Center | Brooklyn, New York 11203 |
Ralph Lauren Center for Cancer Care and Prevention | New York, New York 10035 |
UPMC Cancer Center at Beaver Medical Center | Beaver, Pennsylvania 15009 |
UPMC Cancer Center at Jefferson Regional Medical Center | Clairton, Pennsylvania 15025 |
UPMC Cancer Center - Arnold Palmer Pavilion | Greensburg, Pennsylvania 15601 |
UPMC Cancer Center at the John P. Murtha Pavilion | Johnstown, Pennsylvania 15901 |
UPMC - Moon | Moon Township, Pennsylvania 15108 |
UPMC Cancer Center - Natrona Heights | Natrona Heights, Pennsylvania 15065 |
Jameson Memorial Hospital - North Campus | New Castle, Pennsylvania 16105 |
UPMC - Shadyside | Pittsburgh, Pennsylvania 15213-2582 |
UPMC Cancer Center at UPMC St. Margaret | Pittsburgh, Pennsylvania 15215 |
St. Clair Memorial Hospital Cancer Center | Pittsburgh, Pennsylvania 15243 |
UPMC Cancer Center at UPMC Passavant | Pittsburgh, Pennsylvania 15237 |
UPMC Cancer Center at UPMC Northwest | Seneca, Pennsylvania 16346 |
Washington Hospital Cancer Center | Washington, Pennsylvania 15301 |
Hematology and Oncology Associates of Rhode Island | Cranston, Rhode Island 02920 |
Blue Ridge Medical Specialists, PC | Bristol, Tennessee 37620 |
Princeton Community Hospital | Princeton, West Virginia 24740 |