Inclusion Criteria

Key Inclusion criteria:

- male or female patients of 18 years of age or older, scheduled or expected to receive
at least two cycles of chemotherapy over at least a two- month period as primary or
adjuvant therapy for any malignancy,

- have experienced NCI Common Toxicity Grade 1 - 4 diarrhea during previous
chemotherapy treatment or are currently experiencing Grade 1-4 diarrhea due to
chemotherapy treatment

Key Exclusion criteria:

- females who are pregnant or lactating,

- current use of anticoagulants, except for those who are receiving 1 mg/per day of
Coumadin for port maintenance,

- known hypersensitivity to Sandostatin, Sandostatin LAR ® Depot or other related drug
or compound,

- history or presence of Crohn™s disease, ulcerative colitis, sprue, or known C.
difficile infection, or any other diarrheal syndrome,

- WBC < 3000 /L, Platelets < 75,000 /L, serum creatinine >2.0 mg/dL