Cytogenetic Studies For Previously Untreated AML, ALL or MDS Patients (Companion To CALGB Treatment Studies For Previously Untreated AML, ALL Or MDS Patients)
N/A
15 Years
N/A
15 Years
N/A
Not Enrolling
Both
Leukemia, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
Both
Leukemia, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
Trial Information
Cytogenetic Studies For Previously Untreated AML, ALL or MDS Patients (Companion To CALGB Treatment Studies For Previously Untreated AML, ALL Or MDS Patients)
OBJECTIVES:
- Determine the incidence of chromosomal abnormalities in patients with acute myeloid
leukemia, acute lymphoblastic leukemia, myelodysplastic syndromes, or multiple myeloma.
- Correlate specific chromosomal abnormalities with clinical and laboratory parameters in
these patients.
- Correlate specific karyotype groups with treatment response rates, response duration,
survival, and cure in patients treated with various induction and post-induction
regimens.
- Correlate specific karyotype groups with multidrug resistance data in these patients.
- Identify new chromosome abnormalities important in leukemogenesis.
- Correlate specific karyotype groups with epidemiological data (toxic exposure and
family history) in these patients.
- Determine karyotype changes at relapse and the influence of the type of change (or no
change) in karyotype at relapse in subsequent clinical courses in these patients.
- Correlate specific karyotype groups with selected molecular abnormalities as studied in
CALGB leukemia protocols.
OUTLINE: This is a multicenter study.
Patients undergo collection of bone marrow and blood specimens for cytogenetic analysis at
diagnosis, complete remission, and relapse. Specimens are karyotyped and examined for
chromosomal abnormalities.
PROJECTED ACCRUAL: Approximately 6,400 patients will be accrued for this study.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Must enroll (within 1 month of registration on this study) on a CALGB treatment study
for previously untreated acute myeloid leukemia, acute lymphoblastic leukemia, or
myelodysplastic syndromes
- Patients enrolled on CLB-100001 (previously treated or untreated multiple myeloma)
must enroll on this study
- Simultaneous registration on CLB-9665 (within the continental United States)
PATIENT CHARACTERISTICS:
Age
- 15 and over
Performance status
- Not specified
Life expectancy
- Not specified
Hematopoietic
- Not specified
Hepatic
- Not specified
Renal
- Not specified
PRIOR CONCURRENT THERAPY:
Biologic therapy
- Not specified
Chemotherapy
- Not specified
Endocrine therapy
- Not specified
Radiotherapy
- Not specified
Surgery
- Not specified
Type of Study:
Interventional
Study Design:
Primary Purpose: Diagnostic
Principal Investigator
Clara D. Bloomfield, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Ohio State University Comprehensive Cancer Center
Authority:
Unspecified
Study ID:
CALGB-8461
NCT ID:
NCT00048958
Start Date:
June 1984
Completion Date:
Related Keywords:
- Leukemia
- Multiple Myeloma and Plasma Cell Neoplasm
- Myelodysplastic Syndromes
- Myelodysplastic/Myeloproliferative Neoplasms
- untreated adult acute lymphoblastic leukemia
- untreated adult acute myeloid leukemia
- de novo myelodysplastic syndromes
- secondary myelodysplastic syndromes
- untreated childhood acute lymphoblastic leukemia
- untreated childhood acute myeloid leukemia and other myeloid malignancies
- myelodysplastic/myeloproliferative neoplasm, unclassifiable
- multiple myeloma
- adult acute myeloid leukemia with t(8;21)(q22;q22)
- adult acute myeloid leukemia with t(16;16)(p13;q22)
- adult acute myeloid leukemia with inv(16)(p13;q22)
- adult acute myeloid leukemia with 11q23 (MLL) abnormalities
- adult acute myeloid leukemia with t(15;17)(q22;q12)
- childhood myelodysplastic syndromes
- Neoplasms
- Leukemia
- Leukemia, Lymphoid
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Leukemia, Myeloid, Acute
- Leukemia, Myeloid
- Multiple Myeloma
- Neoplasms, Plasma Cell
- Plasmacytoma
- Myelodysplastic Syndromes
- Preleukemia
- Myeloproliferative Disorders
- Myelodysplastic-Myeloproliferative Diseases
Name | Location |
|---|---|
| Roswell Park Cancer Institute | Buffalo, New York 14263 |
| University of Chicago Cancer Research Center | Chicago, Illinois 60637 |
| CCOP - Christiana Care Health Services | Wilmington, Delaware 19899 |
| CCOP - Mount Sinai Medical Center | Miami Beach, Florida 33140 |
| CCOP - North Shore University Hospital | Manhasset, New York 11030 |
| CCOP - Illinois Oncology Research Association | Peoria, Illinois 61602 |
| Methodist Medical Center of Illinois | Peoria, Illinois 61636 |
| CCOP - Greenville | Greenville, South Carolina 29615 |
| Holden Comprehensive Cancer Center at University of Iowa | Iowa City, Iowa 52242-1002 |
| CCOP - Grand Rapids | Grand Rapids, Michigan 49503 |
| Ellis Fischel Cancer Center at University of Missouri - Columbia | Columbia, Missouri 65203 |
| Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | Lebanon, New Hampshire 03756-0002 |
| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Chapel Hill, North Carolina 27599-7570 |
| Naval Medical Center - San Diego | San Diego, California 92134-3202 |
| Veterans Affairs Medical Center - Minneapolis | Minneapolis, Minnesota 55417 |
| Rebecca and John Moores UCSD Cancer Center | La Jolla, California 92093-0658 |
| Fletcher Allen Health Care - University Health Center Campus | Burlington, Vermont 05401 |
| Sunrise Hospital and Medical Center | Las Vegas, Nevada 89109-2306 |
| Maine Center for Cancer Medicine and Blood Disorders - Scarborough | Scarborough, Maine 04074 |
| Washington Cancer Institute at Washington Hospital Center | Washington, District of Columbia 20010 |
| Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center | Baltimore, Maryland 21237 |
| Long Island Jewish Medical Center | New Hyde Park, New York 11040 |
| Mount Sinai Medical Center | New York, New York 10029 |
| SUNY Upstate Medical University Hospital | Syracuse, New York 13210 |
| Mission Hospitals - Memorial Campus | Asheville, North Carolina 28801 |
| Presbyterian Cancer Center at Presbyterian Hospital | Charlotte, North Carolina 28233-3549 |
| Wake Forest University Comprehensive Cancer Center | Winston-Salem, North Carolina 27157-1096 |
| Rhode Island Hospital Comprehensive Cancer Center | Providence, Rhode Island 02903 |
| CCOP - Hematology-Oncology Associates of Central New York | East Syracuse, New York 13057 |
| Batte Cancer Center at Northeast Medical Center | Concord, North Carolina 28025 |
| Battle Creek Health System Cancer Care Center | Battle Creek, Michigan 49017 |
| Munson Medical Center | Traverse City, Michigan 49684 |
| Wayne Memorial Hospital, Incorporated | Goldsboro, North Carolina 27534 |
| Greenebaum Cancer Center at University of Maryland Medical Center | Baltimore, Maryland 21201 |
| UNMC Eppley Cancer Center at the University of Nebraska Medical Center | Omaha, Nebraska 68198-7680 |
| New York Weill Cornell Cancer Center at Cornell University | New York, New York 10021 |
| UCSF Helen Diller Family Comprehensive Cancer Center | San Francisco, California 94115 |
| Lombardi Comprehensive Cancer Center at Georgetown University Medical Center | Washington, District of Columbia 20007 |
| University of Illinois Cancer Center | Chicago, Illinois 60612-7243 |
| CancerCare of Maine at Eastern Maine Medical Center | Bangor, Maine 04401 |
| Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute | Boston, Massachusetts 02115 |
| Butterworth Hospital at Spectrum Health | Grand Rapids, Michigan 49503-2560 |
| Masonic Cancer Center at University of Minnesota | Minneapolis, Minnesota 55455 |
| Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | St. Louis, Missouri 63110 |
| CCOP - Nevada Cancer Research Foundation | Las Vegas, Nevada 89109-2306 |
| Don Monti Comprehensive Cancer Center at North Shore University Hospital | Manhasset, New York 11030 |
| Oklahoma University Cancer Institute | Oklahoma City, Oklahoma 73104 |
| Virginia Commonwealth University Massey Cancer Center | Richmond, Virginia 23298-0037 |
| University Medical Center of Southern Nevada | Las Vegas, Nevada 89102 |
| Kaiser Permanente Medical Office -Vandever Medical Office | San Diego, California 92120 |
| Ella Milbank Foshay Cancer Center at Jupiter Medical Center | Jupiter, Florida 33458 |
| St. Joseph Medical Center | Bloomington, Illinois 61701 |
| Graham Hospital | Canton, Illinois 61520 |
| Memorial Hospital | Carthage, Illinois 62321 |
| Eureka Community Hospital | Eureka, Illinois 61530 |
| Mason District Hospital | Havana, Illinois 62644 |
| McDonough District Hospital | Macomb, Illinois 61455 |
| BroMenn Regional Medical Center | Normal, Illinois 61761 |
| Community Cancer Center | Normal, Illinois 61761 |
| Community Hospital of Ottawa | Ottawa, Illinois 61350 |
| Oncology Hematology Associates of Central Illinois, PC - Ottawa | Ottawa, Illinois 61350 |
| Cancer Treatment Center at Pekin Hospital | Pekin, Illinois 61554 |
| Oncology Hematology Associates of Central Illinois, PC - Peoria | Peoria, Illinois 61615 |
| OSF St. Francis Medical Center | Peoria, Illinois 61637 |
| Proctor Hospital | Peoria, Illinois 61614 |
| Illinois Valley Community Hospital | Peru, Illinois 61354 |
| Perry Memorial Hospital | Princeton, Illinois 61356 |
| Fort Wayne Medical Oncology and Hematology | Fort Wayne, Indiana 46815 |
| St. Luke's Hospital | Cedar Rapids, Iowa 52402 |
| Mercy Regional Cancer Center at Mercy Medical Center | Cedar Rapids, Iowa 52403 |
| Mecosta County Medical Center | Big Rapids, Michigan 49307 |
| Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center | Grand Island, Nebraska 68803 |
| Cancer Institute of New Jersey at Cooper - Voorhees | Voorhees, New Jersey 08043 |
| Charles R. Wood Cancer Center at Glens Falls Hospital | Glens Falls, New York 12801 |
| Forsyth Regional Cancer Center at Forsyth Medical Center | Winston-Salem, North Carolina 27103 |
| Mountainview Medical | Berlin, Vermont 05602 |
| Danville Regional Medical Center | Danville, Virginia 24541 |
| Massachusetts General Hospital | Boston, Massachusetts 02114-2617 |
| Missouri Baptist Cancer Center | St. Louis, Missouri 63131 |
| Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital | Pittsburgh, Pennsylvania 15224-1791 |
| Tunnell Cancer Center at Beebe Medical Center | Lewes, Delaware 19958 |
| Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital | Fort Lauderdale, Florida 33308 |
| Evanston Hospital | Evanston, Illinois 60201-1781 |
| Menorah Medical Center | Overland Park, Kansas 66209 |
| Saint Luke's Hospital - South | Overland Park, Kansas 66213 |
| St. Luke's Hospital Cancer Care Center | Duluth, Minnesota 55805 |
| Heartland Hematology Oncology Associates, Incorporated | Kansas City, Missouri 64118 |
| North Kansas City Hospital | Kansas City, Missouri 64116 |
| Saint Luke's Cancer Institute at Saint Luke's Hospital | Kansas City, Missouri 64111 |
| Research Medical Center | Kansas City, Missouri 64132 |
| Saint Luke's East - Lee's Summit | Lee's Summit, Missouri 64086 |
| Heartland Regional Medical Center | Saint Joseph, Missouri 64506 |
| Saint Joseph Oncology, Incorporated | Saint Joseph, Missouri 64507 |
| Monter Cancer Center of the North Shore-LIJ Health System | Lake Success, New York 11042 |
| Leo W. Jenkins Cancer Center at ECU Medical School | Greenville, North Carolina 27834 |
| Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center | Columbus, Ohio 43210-1240 |
| Pardee Memorial Hospital | Hendersonville, North Carolina 28791 |
| Harold Alfond Center for Cancer Care | Augusta, Maine 04330 |
| Union Hospital of Cecil County | Elkton MD, Maryland 21921 |
| Dana-Farber/Brigham and Women's Cancer Center | Boston, Massachusetts 02115 |
| Duke Cancer Institute | Durham, North Carolina 27710 |
| Kinston Medical Specialists | Kinston, North Carolina 28501 |
| Miriam Hospital | Providence, Rhode Island 02906 |
| Greenville Hospital Cancer Center | Greenville, South Carolina 29605 |
| Cancer Centers of the Carolinas - Grove Commons | Greenville, South Carolina 29605 |
| Cancer Centers of the Carolinas - Faris Road | Greenville, South Carolina 29605 |
| Cancer Centers of the Carolinas - Greer Medical Oncology | Greer, South Carolina 29650 |
| Cancer Centers of the Carolinas - Seneca | Seneca, South Carolina 29672 |
| Cancer Centers of the Carolinas - Spartanburg | Spartanburg, South Carolina 29307 |
| McLeod Regional Medical Center | Florence, South Carolina 29501 |
| Cancer Centers of the Carolinas - Eastside | Greenville, South Carolina 29601 |
| Lacks Cancer Center at Saint Mary's Health Care | Grand Rapids, Michigan 49503 |
| Galesburg Clinic, PC | Galesburg, Illinois 61401 |
| Parvin Radiation Oncology | Kansas City, Missouri 64116 |
| Illinois CancerCare - Bloomington | Bloomington%, Illinois 61701 |
| Illinois CancerCare - Canton | Canton, Illinois 61520 |
| Illinois CancerCare - Carthage | Carthage, Illinois 62321 |
| Illinois CancerCare - Eureka | Eureka, Illinois 61530 |
| Illinois CancerCare - Galesburg | Galesburg, Illinois 61401 |
| Illinois CancerCare - Havana | Havana, Illinois 62644 |
| Illinois CancerCare - Kewanee Clinic | Kewanee, Illinois 61443 |
| Illinois CancerCare - Macomb | Macomb, Illinois 61455 |
| OSF Holy Family Medical Center | Monmouth, Illinois 61462 |
| Illinois CancerCare - Monmouth | Monmouth, Illinois 61462 |
| Illinois CancerCare - Community Cancer Center | Normal, Illinois 61761 |
| Illinois CancerCare - Pekin | Pekin, Illinois 61603 |
| Illinois CancerCare - Peru | Peru, Illinois 61354 |
| Illinois CancerCare - Princeton | Princeton, Illinois 61356 |
| Illinois CancerCare - Spring Valley | Spring Valley, Illinois 61362 |
| Iowa Blood and Cancer Care | Cedar Rapids, Iowa 52402 |
| Mercy General Health Partners | Muskegon, Michigan 49443 |
| Callahan Cancer Center at Great Plains Regional Medical Center | North Platte, Nebraska 69103 |
| Camino Medical Group - Treatment Center | Mountain View, California 94040 |
| CCOP - Kansas City | Prairie Village, Kansas 66208 |
| Southeast Cancer Center | Cape Girardeau, Missouri 63703 |
| Goldschmidt Cancer Center | Jefferson City, Missouri 65109 |
| Spectrum Health Reed City Hospital | Reed City, Michigan 49677 |
