Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of d-MPH in the Treatment of Fatigue and Neurobehavioral Impairment Related to Chemotherapy in Adult Cancer Patients

Inclusion Criteria

- Diagnosis of cancer, excluding primary or metastatic brain tumors.

- Treated with a minimum of four cycles of a cytotoxic chemotherapy, the last
chemotherapy treatment must have been completed at least 2 months prior to study
entry.

- Physical/neurological examination consistent with the absence of a focal neurological
deficit

- Women of childbearing potential (WCBP) must have a negative serum or urine pregnancy
test. In addition, sexually active WCBP must agree to use adequate contraceptive
methods (oral, injectable, or implantable hormonal contraceptive; tubal ligation;
intra-uterine device; barrier contraceptive with spermicide; or vasectomized
partner).

- Subjects must be able to adhere to the protocol requirements.

- Subjects must understand and voluntarily sign an informed consent document.

- Subjects must be a native English speaker or fluent in English, and have at least an
eighth grade education.