Inclusion Criteria:

- Histologic or cytologic diagnosis of non-small cell lung carcinoma

- Progressed while on or after treatment on platinum-based regimen

- Patients may not have had more than one prior cytotoxic chemotherapy regimen

- Stage IV or IIIB

- Age at least 18 years

- Adequate liver and kidney function

- Adequate bone marrow function

Exclusion Criteria:

- Pregnancy or lactation

- Unstable medical conditions

- Chemotherapy, hormonal therapy, radiotherapy, radiopharmaceuticals or immunotherapy
within 3 weeks of TLK286

- CNS metastasis unless controlled by treatment