Inclusion Criteria:

1. Relapsed or refractory chronic lymphocytic leukemia.

2. Patients must have either intermediate or high risk chronic lymphocytic leukemia
according to the Rai Staging System.

3. Must have failed at least 1 prior chemotherapy regimen (at least 1 of which included
fludarabine) for CLL.

4. No prior therapy within 4 weeks prior to entering the study. Patients must have fully
recovered from the acute effects of prior therapy.

5. Platelet count = 75,000/mm3 , hemoglobin = 8 gm/dL.

6. Expected remaining life span > or = three months.

7. ECOG performance status 0 - 2.

8. 18 years or of legal age.

9. Male patients or non-pregnant and non-lactating female patients, who are either using
adequate birth control, are surgically sterile or post-menopausal.

10. Negative serum pregnancy test, if fertile female.

11. Willingness and ability to sign an informed consent document.

Exclusion Criteria:

1. Evidence of CNS involvement.

2. Other active malignancy or history of treatment of any malignancy (excluding
non-melanoma skin cancer) within the previous three years.

3. Previous therapy with Campath.

4. Patients with low-risk chronic lymphocytic leukemia according to the Rai Staging
System.

5. Concurrent immunotherapy.

6. Concurrent use of steroids.

7. Use of an investigational medication or device within 1 month of initiating study
therapy.

8. Patients who have had allogeneic bone marrow transplantation.

9. Total serum bilirubin above the upper limit of normal; serum creatinine above the
upper limit of normal.

10. AST or ALT > 2.5 times the upper limit of normal.

11. Any condition or any medication which may interfere with the conduct of the study.