Inclusion Criteria:

- You must have been diagnosed with bladder cancer that has recurred or moved to a new
part of the body.

- You must have at least one tumor that can be physically measured or scanned by x-ray.

- You may not have had previous chemotherapy (drug) treatment OR you have had surgery
followed by one chemotherapy treatment at least 4 months ago.

Exclusion Criteria:

- You may not have used an experimental medicine or device within the past month.

- Cancer that has spread to your brain.

- If you are unwilling or unable to take folic acid or vitamin B12 supplements.