Phase I, Multicenter, Open Label, Dose Escalation Of 90Y-Zevalin Radioimmunotherapy Using A Modified Treatment Regimen For Relapsed Or Refractory CD20+ B-Cell (Follicular/Transformed) Non-Hodgkin's Lymphoma

Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically confirmed low-grade, follicular, or transformed CD20-positive B-cell
non-Hodgkin's lymphoma (NHL)

- Relapsed after prior chemotherapy OR chemotherapy-resistant disease

- Failed at least 1 prior chemotherapy regimen

- CD20-positive B-cell population in lymph nodes or bone marrow for International
Working Formulation A (small lymphocytic lymphoma) and transformed NHL

- Bone marrow involvement with lymphoma less than 25% bilaterally

- No impaired bone marrow reserve defined as at least 1 of the following criteria:

- Prior myeloablative therapies with bone marrow transplantation or peripheral
blood stem cell rescue

- Platelet count less than 100,000/mm3

- Bone marrow cellularity no greater than 15%

- Marked reduction in bone marrow precursors of one or more cell lines (e.g.,
granulocytic, megakaryocytic, or erythroid)

- Failed prior stem cell collection

- No CNS lymphoma, chronic lymphocytic lymphoma, or HIV or AIDS-related lymphoma

- No diffuse small lymphocytic/marginal zone lymphoma with lymphocyte count greater
than 5,000/mm^3

- No pleural effusion NOTE: A new classification scheme for adult non-Hodgkin's
lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive"
lymphoma will replace the former terminology of "low", "intermediate", or "high"
grade lymphoma. However, this protocol uses the former terminology.

PATIENT CHARACTERISTICS:

Age:

- 19 and over

Performance status:

- WHO 0-2

Life expectancy:

- At least 6 months

Hematopoietic:

- See Disease Characteristics

- Absolute neutrophil count at least 1,500/mm^3

- Platelet count at least 100,000/mm^3

- Hematocrit greater than 30%

- Hemoglobin greater than 9.0 g/dL

Hepatic:

- Bilirubin no greater than 1.5 mg/dL

Renal:

- Creatinine no greater than 1.5 mg/dL

Other:

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for 6 months after study
participation

- No anti-murine antibody reactivity if prior exposure to murine antibodies or proteins

- No other primary malignancy

- No other serious nonmalignant disease or infection that would preclude study
participation

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- See Disease Characteristics

- No prior radioimmunotherapy

- Prior rituximab allowed if more than 6 months to progression after an objective
response

- At least 6 weeks since prior rituximab

- At least 3 weeks since prior filgrastim (G-CSF) or sargramostim (GM-CSF)

- Recovered from prior immunotherapy

Chemotherapy:

- See Disease Characteristics

- No prior fludarabine

- At least 3 weeks since prior anticancer chemotherapy (6 weeks for nitrosoureas or
mitomycin) and recovered

- No concurrent chemotherapy

Endocrine therapy:

- At least 3 weeks since prior anticancer endocrine therapy

- No concurrent high-dose systemic corticosteroids (e.g., 50 mg or more of prednisone
as a single dose or 50 mg or less of prednisone for more than 6 doses)

Radiotherapy:

- No prior radiotherapy to more than 25% of active bone marrow (involved field or
regional)

- At least 3 weeks since prior anticancer radiotherapy and recovered

Surgery:

- At least 4 weeks since prior surgery (except diagnostic surgery) and recovered

Other:

- No other concurrent anticancer therapy

- Concurrent oral anticoagulant therapy allowed if platelet count is at least
30,000/mm3