Assessment of the Effects of Raloxifene on Salivary Estradiol and Progesterone Levels

Trial Information

Assessment of the Effects of Raloxifene on Salivary Estradiol and Progesterone Levels

Deviations from normal levels of serum E(2) and P are of interest in evaluating ovarian
function. However, the day-to-day variations in these levels necessitates serial blood
sampling or elaborate efforts to time blood draws within specific phases of the menstrual
cycle. A noninvasive method for assessment of the levels of sex steroids on a daily basis
using saliva has been developed. This study will assess the levels of estradiol and
progesterone during 3 menstrual cycles (pre-drug and after 3 and 12 months of raloxifene
therapy) in pre-menopausal women participating in a pilot chemoprevention trial of
raloxifene.