Vaccination In Peripheral Stem Cell Transplant Setting For Multiple Myeloma: The Use Of Autologous Tumor Cells/An Allo PSCT

Inclusion Criteria

DISEASE CHARACTERISTICS:

- Newly diagnosed multiple myeloma

- More than 30% bone marrow involvement

- Eligible for autologous peripheral blood stem cell transplantation

PATIENT CHARACTERISTICS:

Age:

- 18 to 70

Performance status:

- ECOG 0-2

Life expectancy:

- Not specified

Hematopoietic:

- Absolute neutrophil count greater than 500/mm^3

- Platelet count greater than 30,000/mm^3

Hepatic:

- Bilirubin less than 3 times normal

- AST/ALT less than 3 times normal

Renal:

- Not specified

Other:

- Not pregnant

- HIV negative

- No prior or active autoimmune disease

- No other prior malignancy within the past 5 years

- No major active medical or psychosocial problems

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- See Disease Characteristics

Chemotherapy:

- No more than 1 prior course of chemotherapy

Endocrine therapy:

- Not specified

Radiotherapy:

- Concurrent local radiotherapy allowed

Surgery:

- Not specified