Phase II Study of Paclitaxel and Estramustine Phosphate in Patients With Relapsed Non-Hodgkin's Lymphoma
OBJECTIVES: I. Determine the response rate, time to treatment failure, and overall survival
of patients with relapsed or refractory non-Hodgkin's lymphoma treated with paclitaxel and
estramustine. II. Determine the toxicity of this regimen in this patient population.
OUTLINE: Patients receive oral estramustine 2-3 times daily on days 1-3 and paclitaxel IV
over 1 hour on day 2 on weeks 1-6. Treatment repeats every 8 weeks for at least 1 course in
the absence of disease progression or unacceptable toxicity. Patients achieving a complete
or partial response continue therapy for at least 3 courses or for 1 course after achieving
maximum response. Patients are followed every 3 months.
PROJECTED ACCRUAL: A total of 18-35 patients will be accrued for this study.
Interventional
Primary Purpose: Treatment
Mitchell R. Smith, MD, PhD
Study Chair
Fox Chase Cancer Center
United States: Federal Government
CDR0000068773
NCT00021372
February 1996
September 2006
Name | Location |
---|---|
Fox Chase Cancer Center | Philadelphia, Pennsylvania 19111 |
Community Medical Center | Toms River, New Jersey 08755 |
St. Francis Medical Center | Trenton, New Jersey 08629 |
Delaware County Memorial Hospital | Drexel Hill, Pennsylvania 19026 |
Reading Hospital and Medical Center | Reading, Pennsylvania 19612-6052 |
South Jersey Regional Cancer Center | Millville, New Jersey 08332 |
Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County | Mount Holly, New Jersey 08060 |
Hunterdon Regional Cancer Center | Flemington, New Jersey 08822 |
Kimball Medical Center | Lakewood, New Jersey 08701 |
Riverview Medical Center - Booker Cancer Center | Red Bank, New Jersey 07701 |
Saint Mary Regional Center | Langhorne, Pennsylvania 19047 |
North Penn Hospital | Lansdale, Pennsylvania 19446-1200 |
Paoli Memorial Hospital | Paoli, Pennsylvania 19301-1792 |
Pinnacle Health Hospitals | Harrisburg, Pennsylvania 17105-8700 |
Conemaugh Memorial Hospital | Johnstown, Pennsylvania 15905 |
Pottstown Memorial Regional Cancer Center | Pottstown, Pennsylvania 19464 |
Bon Secours-Holy Family Health System | Altoona, Pennsylvania 16602 |