Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically or cytologically confirmed solid tumor for which
no curative therapy exists No symptomatic or uncontrolled brain or leptomeningeal
metastasis

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy:
Not specified Hematopoietic: WBC greater than 3,000/mm3 Absolute neutrophil count at least
1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than upper
limit of normal (ULN) AST no greater than 1.5 times ULN Renal: Creatinine no greater than
ULN Cardiovascular: No unstable cardiac disease requiring treatment No new onset crescendo
or rest angina Stable exertion angina allowed Other: Not pregnant or nursing Negative
pregnancy test Fertile patients must use 2 methods of contraception for at least 1 week
prior to study, during study, and for at least 2 weeks after study No symptomatic
peripheral neuropathy greater than grade 1 No significant neurologic or psychiatric
disorders including psychotic disorders, dementia, or seizures No other significant
medical or psychiatric condition that would preclude study No active infection No other
malignancy within past 5 years except non-melanoma skin cancer, carcinoma in situ of the
cervix, or other cancer that, due to its stage, is highly unlikely to recur during
treatment No known hypersensitivity to E. coli-derived products

PRIOR CONCURRENT THERAPY: Biologic therapy: No other concurrent prophylactic hematopoietic
growth factors (i.e., filgrastim (G-CSF) or sargramostim (GM-CSF)) Chemotherapy: No more
than 1 prior chemotherapy regimen for advanced disease At least 3 weeks since prior
chemotherapy (6 weeks for mitomycin or nitrosoureas) and recovered Prior cisplatin,
carboplatin, docetaxel, paclitaxel, or gemcitabine allowed No other concurrent
chemotherapy Endocrine therapy: At least 3 weeks since prior hormonal therapy and
recovered Radiotherapy: At least 3 weeks since prior radiotherapy and recovered No
concurrent radiotherapy Surgery: Not specified Other: At least 3 weeks since prior
investigational drugs and recovered No other concurrent experimental agents No other
concurrent anti-cancer therapy No concurrent prophylactic oral or IV antibiotics without
fever present