Esophageal Cancer: A Phase II Study of Paclitaxel, Carboplatin and 5-Fluorouracil With Simultaneous Radiotherapy Followed by Surgical Resection
OBJECTIVES: I. Determine the total response rate in patients with stage I, II, or III
esophageal cancer treated with paclitaxel, carboplatin, and fluorouracil with concurrent
radiotherapy followed by surgical resection. II. Determine the overall survival of these
patients treated with this regimen. II. Determine the toxicity of this regimen in this
patient population.
OUTLINE: Patients receive paclitaxel IV over 1 hour followed by carboplatin IV over 30
minutes on days 1 and 22, and fluorouracil IV continuously on days 1-42. Patients undergo
radiotherapy concurrently with chemotherapy daily 5 days a week for 5 weeks. Patients then
undergo surgical resection within 3-5 weeks following completion of therapy. Patients are
followed every 3 months for 6 months, every 6 months for 1 year, and then annually
thereafter.
PROJECTED ACCRUAL: A total of 47 patients will be accrued for this study.
Interventional
Primary Purpose: Treatment
David J. Perry, MD
Study Chair
Washington Hospital Center
United States: Federal Government
CDR0000068295
NCT00006472
January 2000
Name | Location |
---|---|
Harbor Hospital Center | Baltimore, Maryland 21225 |
Franklin Square Hospital Center | Baltimore, Maryland 21237 |
Washington Cancer Institute | Washington, District of Columbia 20010 |
Washington Hospital Center | Washington, District of Columbia 20010 |
Union Memorial Hospital | Baltimore, Maryland 21218 |
Good Samaritan Hospital of Maryland | Baltimore, Maryland 21239 |