Fractionated Stereotactic Body Radiosurgery for Extracranial Tumors

Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically or cytologically confirmed malignancy

- Extracranial recurrent or metastatic disease or primary tumor not predicted to
be controlled with standard radiotherapy

- Incurable with any standard therapy

- No tumors involving critical structures (e.g., mucosal surfaces (bowel or bladder) or
heart)

- Tumor visible by CT scan

PATIENT CHARACTERISTICS:

Age:

- Not specified

Performance status:

- Karnofsky 60-100%

Life expectancy:

- Not specified

Hematopoietic:

- Not specified

Hepatic:

- Bilirubin less than 2.0 times upper limit of normal (ULN)

- AST and ALT less than 5 times ULN

Renal:

- Creatinine less than 2.0 mg/dL

Pulmonary:

- FEV1 greater than 0.75 L

Other:

- No unsuitable size or geometric proportion that would preclude stereotactic
immobilization

- Not pregnant or nursing

- Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- At least 14 days since prior anticancer biologic therapy and recovered

Chemotherapy:

- At least 14 days since prior anticancer chemotherapy and recovered

Endocrine therapy:

- At least 14 days since prior anticancer endocrine therapy and recovered

Radiotherapy:

- See Disease Characteristics

- At least 14 days since prior anticancer radiotherapy and recovered

Surgery:

- Not specified