Inclusion Criteria:

- Patients with metastatic RCC following resection of the primary renal tumor
(Pathologic diagnosis and staging of the disease will be completed at time of
surgery).

- Patients must have a performance status of 0 or 1 according the Eastern Cooperative
Oncology Group (ECOG) criteria and must have an estimated life expectancy of 6 months
and more.

- Patients must not have undergone any major surgery during the past 6 weeks. In
addition no chemotherapeutic agents, (standard or experimental) radiation therapy,
(local therapy or palliative treatment for painful bony metastases) or immunotherapy
(i.e. IL-2, interferon-alpha, ALT therapy) can be administered 6 weeks prior to
enrollment. Patients must have recovered from all acute toxicities from prior
treatment.

- Adequate hematologic function with: WBC 3000 mm3, hemoglobin 9 mg/dl, platelets
100,000/mm3

- Patients may be transfused to meet the eligibility criteria.

- Adequate renal and hepatic function with: serum creatinine < 2.5 mg/dl, bilirubin <
2.0 mg/dl

- Adequate coagulation parameters with: Partial thromboplastin time < 1.5 x control

- Ability to understand and provide signed inform consent that fulfills Institutional
Review Board guidelines

- Ability to return to Duke University Medical Center for adequate follow-up as
required by this protocol.

Exclusion Criteria:

- Women who are pregnant and nursing women are excluded.

- Patients after radical nephrectomy are excluded since no tumor tissue can be
retrieved and no vaccine generated.

- Patients with either previously irradiated or new CNS (central nervous system)
metastases as determined by enhanced cranial CT or MRI prior to enrollment.

- Patients with a history of autoimmune disease such as, but not restricted to,
inflammatory bowel disease, systemic lupus erythematosus, ankylosing spondylitis,
scleroderma, or multiple sclerosis.

- Patients with serious intercurrent chronic or acute illness such as pulmonary (asthma
or COPD) or cardiac (NYHA class III or IV) or hepatic disease or other illness
considered by the P.I. to constitute an unwarranted high risk for investigational
drug treatment.

- Medical or psychological impediment to probable compliance with the protocol.

- Patients with prior history of another malignancy within the last 5 years (excluding
basal cell carcinoma, carcinoma in situ of the cervix, non-melanoma skin cancer, or
controlled superficial bladder cancer).

- Presence of an active acute or chronic infection, including symptomatic urinary tract
infection, HIV (as determined by ELISA and confirmed by Western Blot), viral
hepatitis (as determined by HBsAg and Hepatitis C serology) and surgical site
infection following nephrectomy. Any postoperative complication rendering
experimental therapy unduly hazardous i.e. deep venous thrombosis (DVT) or pulmonary
embolism will exclude eligibility from study.

- Patients on steroid therapy (or other immunosuppressive agents such as azathioprine
or cyclosporine A) are excluded on the basis of potential immune suppression.
Patients must have had 6 weeks of discontinuation of any steroid therapy prior to
enrollment.

- Patients with serum calcium >12 mg/dl or symptomatic hypercalcemia. Documented active
treatment for hypercalcemia is allowed.

- Patients with inadequate peripheral vein access to perform leukapheresis.