Conformal and Intensity Modulated Irradiation for Oropharyngeal Cancer
OBJECTIVES:
- Assess target coverage and major salivary gland sparing in patients with stage II or
III oropharyngeal cancer treated with intensity-modulated radiotherapy.
- Determine the nature and prevalence of acute and late side effects of this treatment in
these patients.
- Determine the rate and pattern of locoregional tumor recurrence in these patients after
this treatment.
OUTLINE: This is a multicenter study.
Patients receive 3-D conformal radiotherapy and/or intensity-modulated radiotherapy daily 5
days a week for 6 weeks, in an effort to spare major salivary glands.
Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then
annually thereafter.
PROJECTED ACCRUAL: Approximately 57-64 patients will be accrued for this study over 27
months.
Interventional
Primary Purpose: Treatment
Acute salivary gland toxicity
Yes
Avraham Eisbruch, MD
Study Chair
University of Michigan Cancer Center
United States: Federal Government
CDR0000068231
NCT00006360
February 2001
Name | Location |
---|---|
University of Michigan Comprehensive Cancer Center | Ann Arbor, Michigan 48109-0752 |
CCOP - Kansas City | Kansas City, Missouri 64131 |
Medical College of Wisconsin Cancer Center | Milwaukee, Wisconsin 53226 |
Dixie Regional Medical Center | Saint George, Utah 84770 |
LDS Hospital | Salt Lake City, Utah 84143 |
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia, Pennsylvania 19107 |
Foundation for Cancer Research and Education | Phoenix, Arizona 85013 |
Monmouth Medical Center | Long Branch, New Jersey 07740-6395 |
UCSF Comprehensive Cancer Center | San Francisco, California 94115 |
M.D. Anderson Cancer Center at University of Texas | Houston, Texas 77030 |
University of Florida Shands Cancer Center | Gainesville, Florida 32610-0232 |
CCOP - Marshfield Clinic Research Foundation | Marshfield, Wisconsin 54449 |
All Saints Cancer Center at All Saints Healthcare | Racine, Wisconsin 53405 |
Community Cancer Center at Rutland Regional Medical Center | Rutland, Vermont 05701 |
Community Regional Cancer Center at Community Medical Center | Toms River, New Jersey 08755 |