Inclusion Criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

Diagnosis of Fanconi's anemia by conventional diepoxybutane or mitomycin sensitivity
assays, or molecular testing

Bone marrow failure verified on at least 3 occasions in the preceding 3 months by any one
of the following: hemoglobin less than 8 g/dL; absolute neutrophil count less than
1,000/mm3; platelet count less than 30,000/mm3; symptomatic bone marrow failure (e.g.,
exercise limitation from anemia or spontaneous bleeding from thrombocytopenia)

Evidence consistent with myelodysplastic syndrome allowed if less than 5% blasts on bone
marrow aspiration; clonality on bone marrow cytogenetic analysis OR morphological changes
on bone marrow aspirate

Refusal of or unsuccessful with prior conventional therapies

--Prior/Concurrent Therapy--

Biologic therapy: No prior bone marrow transplantation; no concurrent hematopoietic growth
factors

Endocrine therapy: No concurrent androgens

--Patient Characteristics--

Hepatic: Bilirubin no greater than 2 times normal AST no greater than 3 times normal ALT
no greater than 6 times normal

Renal: Creatinine no greater than 2 times normal

Other: No prior malignancy; no active bacterial, viral, or fungal infection requiring
therapy other than prophylaxis; not pregnant; negative pregnancy test