A Phase I Pilot Trial to Evaluate the Toxicity of Epstein-Barr Virus Specific T-Lymphocytes or Peripheral Blood Mononuclear Cells for the Treatment of Relapsed/Refractory Hodgkin's Disease

Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically proven Hodgkin's lymphoma

- Progressive, relapsed, or refractory disease after prior chemotherapy,
radiotherapy, and/or stem cell transplantation

- Epstein Barr virus (EBV) positive by immunohistochemical staining for LMP-1 or 2
OR the presence of EBV RNA (EBER)

- Availability of an HLA identical or haploidentical donor for cytotoxic T-lymphocytes,
meeting the following criteria:

- EBV seropositive

- HIV negative

- HTLV-1 negative

- Hepatitis B surface antigen and hepatitis B core antibody IgM negative

- Hepatitis C antibody negative

- Must share at least 1 HLA haplotype with donor

PATIENT CHARACTERISTICS:

Age:

- 18 to 75

Performance status:

- Not specified

Life expectancy:

- At least 8 weeks

Hematopoietic:

- Not specified

Hepatic:

- Bilirubin less than 2.0 mg/dL

- SGOT/SGPT less than 2.5 times normal (unless liver metastases are present)

- If there is liver involvement by disease, an obvious relationship between
SGOT/SGPT and disease activity is required

- No hepatic dysfunction causing moribundity

Renal:

- Creatinine clearance greater than 50 mL/min

- No renal dysfunction causing moribundity

Cardiovascular:

- No cardiac dysfunction causing moribundity

Pulmonary:

- No pulmonary dysfunction causing moribundity

Other:

- No neurologic dysfunction causing moribundity

- No history of severe transfusion reactions with blood products (including fetal calf
serum)

- Not pregnant

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- See Disease Characteristics

Chemotherapy:

- See Disease Characteristics

- No concurrent antimetabolites

Endocrine therapy:

- Not specified

Radiotherapy:

- See Disease Characteristics

Surgery:

- Not specified