Phase II Study of Thalidomide (NSC #66847) in Patients With Sarcomas of Gynecologic Origin
OBJECTIVES:
- Determine the impact on survival and the antitumor effects of thalidomide in patients
with sarcomas or carcinosarcoma (mixed mesodermal tumors) of gynecologic origin.
- Determine the safety and side effect profiles of the target dose of this treatment
regimen in this patient population.
- Determine the antiangiogenic and immunologic effects of this treatment regimen in these
patients.
OUTLINE: Patients receive oral thalidomide daily. Treatment continues in the absence of
disease progression or unacceptable toxicity.
Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then
annually thereafter.
PROJECTED ACCRUAL: A total of 60 patients will be accrued for this study within 18 months.
Interventional
Primary Purpose: Treatment
Scott Wadler, MD
Study Chair
Weill Medical College of Cornell University
United States: Federal Government
CDR0000068013
NCT00006005
September 2000
August 2006
Name | Location |
---|---|
Cancer Center of Albany Medical Center | Albany, New York 12208 |
Mount Sinai School of Medicine | New York, New York 10029 |
NYU School of Medicine's Kaplan Comprehensive Cancer Center | New York, New York 10016 |
New York Medical College | Valhalla, New York 10595 |
University of Wisconsin Comprehensive Cancer Center | Madison, Wisconsin 53792 |
North Shore University Hospital | Manhasset, New York 11030 |
Albert Einstein Clinical Cancer Center | Bronx, New York 10461 |
New York Weill Cornell Cancer Center at Cornell University | New York, New York 10021 |
St. Luke's-Roosevelt Hospital Center - Roosevelt Division | New York, New York 10019 |
St. Vincent's Comprehensive Cancer Center | New York, New York 10011 |