A Phase II Study of Carboplatin and Paclitaxel in Elderly Patients With Metastatic or Recurrent Unresectable Non-Small Cell Lung Cancer
OBJECTIVES: I. Determine the response rate to carboplatin and paclitaxel in elderly patients
with metastatic or recurrent unresectable non-small cell lung cancer. II. Determine the
toxicity of this regimen in these patients. III. Determine if the hypothesized lack of
social support impacts the recruitment of elderly patients into clinical trials. IV.
Determine if a previously validated tool of functional status in the elderly predicts
treatment related toxicity superior to that predicted by the ECOG performance status in this
patient population.
OUTLINE: Following completion of the Lubben Social Network Scale and Frailty Questionnaire,
patients receive carboplatin IV over 30 minutes and paclitaxel IV over 60 minutes on days 1,
8, and 15. Treatment repeats every 28 days for 2 courses. Patients with complete response
receive 2 additional courses of therapy. Patients with partial response or stable disease
may receive additional courses of therapy at investigator's discretion. Patients are
followed every 3 months for 5 years or until disease progression.
PROJECTED ACCRUAL: A total of 49 patients will be accrued for this study over 27 months.
Interventional
Primary Purpose: Treatment
Aminah Jatoi, MD
Study Chair
Mayo Clinic
United States: Federal Government
CDR0000067656
NCT00005059
January 2000
Name | Location |
---|---|
Mayo Clinic Cancer Center | Rochester, Minnesota 55905 |
CCOP - Wichita | Wichita, Kansas 67214-3882 |
CCOP - Missouri Valley Cancer Consortium | Omaha, Nebraska 68131 |
CCOP - Illinois Oncology Research Association | Peoria, Illinois 61602 |
CCOP - Carle Cancer Center | Urbana, Illinois 61801 |
CCOP - Iowa Oncology Research Association | Des Moines, Iowa 50309-1016 |
CCOP - Metro-Minnesota | Saint Louis Park, Minnesota 55416 |
CCOP - Duluth | Duluth, Minnesota 55805 |
CCOP - Scottsdale Oncology Program | Scottsdale, Arizona 85259-5404 |
CCOP - Cedar Rapids Oncology Project | Cedar Rapids, Iowa 52403-1206 |
Siouxland Hematology-Oncology | Sioux City, Iowa 51101-1733 |
CentraCare Clinic | Saint Cloud, Minnesota 56303 |
Quain & Ramstad Clinic, P.C. | Bismarck, North Dakota 58501 |
CCOP - Merit Care Hospital | Fargo, North Dakota 58122 |
CCOP - Toledo Community Hospital Oncology Program | Toledo, Ohio 43623-3456 |
Rapid City Regional Hospital | Rapid City, South Dakota 57709 |
CCOP - Sioux Community Cancer Consortium | Sioux Falls, South Dakota 57105-1080 |
Ann Arbor Hematology Oncology | Ypsilanti, Michigan 48197 |