Phase I/II Radioimmunotherapy of Non-Hodgkin's Lymphoma With High-Dose 90Y-Labeled Humanized LL2 Anti-CD-22 Antibody and Peripheral Blood Stem Cell Rescue

Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically or cytologically proven B cell lymphoma of one of
the following types: Any histologic grade of non-Hodgkin's lymphoma Chronic lymphocytic
leukemia CD22 positive acute lymphocytic leukemia Waldenstrom's macroglobulinemia Must
have failed at least 1 standard therapy Autologous peripheral blood stem cells (PBSC) or
bone marrow available Bone marrow involvement allowed if: Autologous bone marrow or PBSC
with no greater than 5% tumor involvement available Radiation dose to marrow no greater
than 3,000 cGy until 6 patients have been safely treated at that dose level At least 1
confirmed site of tumor targeted by pretherapy indium In 111 monoclonal antibody MN-14
imaging No brain metastases

PATIENT CHARACTERISTICS: Age: 18 to 80 Performance status: Karnofsky 70-100% ECOG 0-2 Life
expectancy: At least 3 months Hematopoietic: WBC at least 3,000/mm3 Granulocyte count at
least 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than 2.0
mg/dL AST and alkaline phosphatase less than 1.5 times upper limit of normal (ULN) in the
absence of bone involvement Renal: Creatinine less than 1.5 times ULN Cardiovascular:
Ejection fraction at least 50% Pulmonary: DLCO at least 60% of predicted Forced vital
capacity at least 60% of predicted Other: No severe anorexia, nausea, or vomiting No
concurrent significant medical complications that would preclude study participation Not
pregnant Negative pregnancy test Fertile patients must use effective contraception during
and for 3 months after study HIV negative

PRIOR CONCURRENT THERAPY: Biologic therapy: No prior radioimmunotherapy AND high dose
chemotherapy Chemotherapy: No prior high dose chemotherapy AND radioimmunotherapy At least
4 weeks since other prior chemotherapy and recovered Endocrine therapy: At least 2 weeks
since prior corticosteroids and recovered Radiotherapy: No prior radioimmunotherapy AND
high dose chemotherapy At least 4 weeks since prior radiotherapy to index lesion No prior
radiotherapy to greater than 25% of any critical organ (e.g., lung, liver, kidneys) No
prior total body irradiation Surgery: At least 4 weeks since prior major surgery