The Incidence and Prognostic Significance of P16 INK4A/ P15 INK4B Gene Alterations in Children With Relapsed ALL Treated on CCG-1941
N/A
17 Years
Both
Leukemia
Trial Information
The Incidence and Prognostic Significance of P16 INK4A/ P15 INK4B Gene Alterations in Children With Relapsed ALL Treated on CCG-1941
OBJECTIVES:
- Determine the incidence of p16/p15 homozygous deletions and p15 promoter
hypermethylation in acute lymphocytic leukemia cells of children treated on protocol
CCG-1941.
- Determine the prognostic importance of p16/p15 abnormalities in these children.
- Determine the presence or absence of p16/p15 abnormalities in the dominant clone at
diagnosis if present at relapse in these patients.
OUTLINE: Frozen cells are obtained from samples collected on protocol CCG-1941. DNA is
isolated and examined using Southern blot analysis to assay for deletions and promoter
hypermethylation of p16 and/or p15.
PROJECTED ACCRUAL: Approximately 100 samples will be obtained for this study.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of acute lymphocytic leukemia and treated on protocol CCG-1941
- Material cryopreserved in the CCG cell bank
PATIENT CHARACTERISTICS:
Age:
- Children
Performance status:
- Not specified
Life expectancy:
- Not specified
Hematopoietic:
- Not specified
Hepatic:
- Not specified
Renal:
- Not specified
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- Not specified
Chemotherapy:
- Not specified
Endocrine therapy:
- Not specified
Radiotherapy:
- Not specified
Surgery:
- Not specified
Other:
- See Disease Characteristics
Type of Study:
Interventional
Study Design:
Primary Purpose: Diagnostic
Principal Investigator
Stephen P. Hunger, MD
Investigator Role:
Study Chair
Investigator Affiliation:
University of Florida
Authority:
United States: Federal Government
Study ID:
CDR0000067125
NCT ID:
NCT00003933
Start Date:
April 1999
Completion Date:
Related Keywords:
- Leukemia
- recurrent childhood acute lymphoblastic leukemia
- Leukemia
- Leukemia, Lymphoid
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
Name | Location |
|---|---|
| Fred Hutchinson Cancer Research Center | Seattle, Washington 98109 |
| Memorial Sloan-Kettering Cancer Center | New York, New York 10021 |
| University of Texas - MD Anderson Cancer Center | Houston, Texas 77030-4009 |
| University of Michigan Comprehensive Cancer Center | Ann Arbor, Michigan 48109-0752 |
| Children's Hospital of Philadelphia | Philadelphia, Pennsylvania 19104 |
| Mayo Clinic Cancer Center | Rochester, Minnesota 55905 |
| Jonsson Comprehensive Cancer Center, UCLA | Los Angeles, California 90095-1781 |
| University of Chicago Cancer Research Center | Chicago, Illinois 60637 |
| Indiana University Cancer Center | Indianapolis, Indiana 46202-5265 |
| University of Minnesota Cancer Center | Minneapolis, Minnesota 55455 |
| Lineberger Comprehensive Cancer Center, UNC | Chapel Hill, North Carolina 27599-7295 |
| Ireland Cancer Center | Cleveland, Ohio 44106-5065 |
| Shands Hospital and Clinics, University of Florida | Gainesville, Florida 32610-100277 |
| Mount Sinai School of Medicine | New York, New York 10029 |
| UCSF Cancer Center and Cancer Research Institute | San Francisco, California 94115-0128 |
| CCOP - Kalamazoo | Kalamazoo, Michigan 49007-3731 |
| Vanderbilt-Ingram Cancer Center | Nashville, Tennessee 37232-6838 |
| CCOP - Merit Care Hospital | Fargo, North Dakota 58122 |
| NYU School of Medicine's Kaplan Comprehensive Cancer Center | New York, New York 10016 |
| David Grant Medical Center | Travis Air Force Base, California 94535 |
| University of Wisconsin Comprehensive Cancer Center | Madison, Wisconsin 53792 |
| Herbert Irving Comprehensive Cancer Center | New York, New York 10032 |
| Holden Comprehensive Cancer Center | Iowa City, Iowa 52242-1009 |
| Veterans Affairs Medical Center - Fargo | Fargo, North Dakota 58102 |
| Cancer Institute of New Jersey | New Brunswick, New Jersey 08901 |
| University of Nebraska Medical Center | Omaha, Nebraska 68198-3330 |
| Long Beach Memorial Medical Center | Long Beach, California 90806 |
| Children's Hospital Los Angeles | Los Angeles, California 90027-0700 |
| Children's Hospital of Orange County | Orange, California 92668 |
| Children's Hospital of Denver | Denver, Colorado 80218 |
| Children's National Medical Center | Washington, District of Columbia 20010-2970 |
| Children's Mercy Hospital | Kansas City, Missouri 64108 |
| Children's Hospital Medical Center - Cincinnati | Cincinnati, Ohio 45229-3039 |
| Children's Hospital of Columbus | Columbus, Ohio 43205-2696 |
| Doernbecher Children's Hospital | Portland, Oregon 97201-3098 |
| Children's Hospital of Pittsburgh | Pittsburgh, Pennsylvania 15213 |
| Children's Hospital and Regional Medical Center - Seattle | Seattle, Washington 98105 |
| Saint Peter's University Hospital | New Brunswick, New Jersey 08901-1780 |
