Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically documented ovarian epithelial cancer Metastatic
and/or locally recurrent disease that is incurable with standard therapy Must have
received 1 or 2 prior regimens of chemotherapy At least 1 regimen must have contained
cisplatin or carboplatin Bidimensionally measurable disease Indicator lesion size must be
as follows: At least 4-50 cm2 by CT scan At least 1 cm2 by chest xray At least 1 cm2
(e.g., nodules) by physical exam No abdominal adenocarcinoma of unknown origin No
borderline ovarian tumor No tumor known to be of primary fallopian tube or peritoneal
origin

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-1 Life expectancy: At
least 12 weeks Hematopoietic: Platelet count at least 100,000/mm3 Absolute granulocyte
count at least 1,500/mm3 No known bleeding disorder Hepatic: Bilirubin no greater than 2
times upper limit of normal (ULN) AST less than 5 times ULN PT/PTT normal (except when
elevated due to therapeutic coumadin) Renal: Creatinine no greater than 2 times ULN
Cardiovascular: No significant cardiac dysfunction Neurologic No history of significant
neurologic disorder No significant psychiatric disorder Other: Not pregnant or nursing
Fertile patients must use effective contraception At least 5 years since prior malignancy
and no evidence of recurrence No other serious illness or medical condition No active
uncontrolled infection No complete bowel obstruction

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: See Disease
Characteristics At least 4 weeks since prior chemotherapy No other concurrent cytotoxic
therapy Endocrine therapy: Not specified Radiotherapy: Recovered from prior radiotherapy
At least 4 weeks since radiotherapy to at least 20% of bone marrow Surgery: Not specified
Other: As least 28 days since prior investigational agent or new anticancer therapy No
concurrent therapeutic heparin No other concurrent investigational therapy