Phase III Trial of Tamoxifen Alone vs. Tamoxifen Plus RT for Good Risk Duct Carcinoma In-Situ (DCIS) of the Female Breast
Phase 3
26 Years
N/A
26 Years
N/A
Open (Enrolling)
Female
Breast Cancer
Female
Breast Cancer
Trial Information
Phase III Trial of Tamoxifen Alone vs. Tamoxifen Plus RT for Good Risk Duct Carcinoma In-Situ (DCIS) of the Female Breast
OBJECTIVES:
- Compare the efficacy of whole breast radiotherapy vs observation with or without
optional tamoxifen in decreasing or delaying the appearance of local failure (both
invasive and in situ) and preventing the need for mastectomy in women with good-risk
ductal carcinoma in situ (DCIS) of the breast.
- Compare distant disease-free survival of patients treated with these regimens.
OUTLINE: This is a randomized, multicenter study. Patients are stratified according to age
(under 50 vs 50 and over), final path margins (negative vs 3-9 mm vs at least 10 mm),
mammographic size of primary (no greater than 1 cm vs greater than 1 cm to 2.5 cm), nuclei
grade (low vs intermediate), and tamoxifen use (yes vs no). Patients are randomized to 1 of
2 treatment arms.
- Arm I: Patients undergo observation and may receive optional oral tamoxifen once daily
(at the discretion of the physician) for 5 years.
- Arm II: Beginning within 12 weeks after final surgery, patients receive radiotherapy to
the whole breast once daily, 5 days a week, for 3.5-5.5 weeks. Patients may receive
optional tamoxifen as in arm I.
Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then
annually thereafter.
PROJECTED ACCRUAL: A total of 1,790 patients will be accrued for this study within 6 years.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Ductal carcinoma in situ (DCIS) of the breast detected by mammogram at the time of
diagnosis
- Unicentric
- Lesions ≤ 2.5 cm
- Low nuclei grade (NG1) or intermediate nuclei grade (NG2) with necrosis in < one
third of the involved ducts
- Inked margins ≥ 3 mm
- Clinically node negative
- Non-palpable
- No suspicious areas on post-operative mammogram taken within 12 weeks after final
surgery
- No bloody nipple discharge
- No more than 12 weeks since prior final surgery (arm II only)
- Hormone receptor status:
- Not specified
PATIENT CHARACTERISTICS:
Age:
- 26 and over
Sex:
- Female
Menopausal status:
- Not specified
Performance status:
- Not specified
Life expectancy:
- Not specified
Hematopoietic:
- Not specified
Hepatic:
- Not specified
Renal:
- Not specified
Other:
- Not pregnant or nursing
- No active connective tissue disorders (e.g., lupus or scleroderma)
- No prior malignancy within the past 5 years except adequately treated basal cell or
squamous cell skin cancer or carcinoma in situ of the cervix
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- Not specified
Chemotherapy:
- No prior chemotherapy
Endocrine therapy:
- No other concurrent hormonal therapy (e.g., raloxifene, hormone replacement therapy,
or birth control pills)
Radiotherapy:
- No prior radiotherapy
Surgery:
- See Disease Characteristics
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Primary Purpose: Treatment
Outcome Measure:
Local recurrence (e.g., invasive or noninvasive recurrence)
Safety Issue:
No
Principal Investigator
Beryl McCormick, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Memorial Sloan-Kettering Cancer Center
Authority:
United States: Federal Government
Study ID:
CDR0000067020
NCT ID:
NCT00003857
Start Date:
December 1999
Completion Date:
Related Keywords:
- Breast Cancer
- breast cancer in situ
- ductal breast carcinoma in situ
- Breast Neoplasms
- Carcinoma
- Carcinoma in Situ
- Carcinoma, Intraductal, Noninfiltrating
Name | Location |
|---|---|
| Suburban Hospital | Bethesda, Maryland 20814 |
| Roswell Park Cancer Institute | Buffalo, New York 14263 |
| Memorial Sloan-Kettering Cancer Center | New York, New York 10021 |
| University of Michigan Comprehensive Cancer Center | Ann Arbor, Michigan 48109-0752 |
| Mayo Clinic - Jacksonville | Jacksonville, Florida 32224 |
| Mayo Clinic Cancer Center | Rochester, Minnesota 55905 |
| Cardinal Bernardin Cancer Center at Loyola University Medical Center | Maywood, Illinois 60153-5500 |
| Indiana University Cancer Center | Indianapolis, Indiana 46202-5265 |
| Barbara Ann Karmanos Cancer Institute | Detroit, Michigan 48201 |
| University of Mississippi Medical Center | Jackson, Mississippi 39216-4505 |
| Duke Comprehensive Cancer Center | Durham, North Carolina 27710 |
| CCOP - Upstate Carolina | Spartanburg, South Carolina 29303 |
| Tripler Army Medical Center | Honolulu, Hawaii 96859-5000 |
| CCOP - Kansas City | Kansas City, Missouri 64131 |
| CCOP - Christiana Care Health Services | Wilmington, Delaware 19899 |
| CCOP - North Shore University Hospital | Manhasset, New York 11030 |
| CCOP - Illinois Oncology Research Association | Peoria, Illinois 61602 |
| CCOP - Carle Cancer Center | Urbana, Illinois 61801 |
| CCOP - Metro-Minnesota | Saint Louis Park, Minnesota 55416 |
| Veterans Affairs Medical Center - East Orange | East Orange, New Jersey 07018-1095 |
| Rush-Copley Cancer Care Center | Aurora, Illinois 60507 |
| Joliet Oncology-Hematology Associates, Limited - West | Joliet, Illinois 60435 |
| Carle Cancer Center at Carle Foundation Hospital | Urbana, Illinois 61801 |
| Saint Anthony Memorial Health Centers | Michigan City, Indiana 46360 |
| Cedar Rapids Oncology Associates | Cedar Rapids, Iowa 52403 |
| Baystate Regional Cancer Program at D'Amour Center for Cancer Care | Springfield, Massachusetts 01199 |
| CCOP - Michigan Cancer Research Consortium | Ann Arbor, Michigan 48106 |
| Genesys Hurley Cancer Institute | Flint, Michigan 48503 |
| Van Elslander Cancer Center at St. John Hospital and Medical Center | Grosse Pointe Woods, Michigan 48236 |
| Foote Hospital | Jackson, Michigan 49201 |
| Bronson Methodist Hospital | Kalamazoo, Michigan 49007 |
| West Michigan Cancer Center | Kalamazoo, Michigan 49007-3731 |
| Borgess Medical Center | Kalamazooaa, Michigan 49001 |
| Seton Cancer Institute - Saginaw | Saginaw, Michigan 48601 |
| St. John Macomb Hospital | Warren, Michigan 48093 |
| Fairview Ridges Hospital | Burnsville, Minnesota 55337 |
| Mercy and Unity Cancer Center at Mercy Hospital | Coon Rapids, Minnesota 55433 |
| Fairview Southdale Hospital | Edina, Minnesota 55435 |
| Mercy and Unity Cancer Center at Unity Hospital | Fridley, Minnesota 55432 |
| Regions Hospital Cancer Care Center | St. Paul, Minnesota 55101 |
| United Hospital | St. Paul, Minnesota 55102 |
| Ridgeview Medical Center | Waconia, Minnesota 55387 |
| Mercy Cancer Center at Mercy Medical Center | Canton, Ohio 44708 |
| Case Comprehensive Cancer Center | Cleveland, Ohio 44106-5065 |
| St. Rita's Medical Center | Lima, Ohio 45801 |
| Natalie Warren Bryant Cancer Center at St. Francis Hospital | Tulsa, Oklahoma 74136 |
| Geisinger Medical Center | Danville, Pennsylvania 17822-0001 |
| Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center | Wilkes-Barre, Pennsylvania 18711 |
| Medical X-Ray Center, PC | Sioux Falls, South Dakota 57105 |
| Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center | La Crosse, Wisconsin 54601 |
| Massachusetts General Hospital Cancer Center | Boston, Massachusetts 02114 |
| Rapid City Regional Hospital | Rapid City, South Dakota 57709 |
| Providence Saint Joseph Medical Center - Burbank | Burbank, California 91505 |
| CCOP - Bay Area Tumor Institute | Oakland, California 94609-3305 |
| CCOP - Santa Rosa Memorial Hospital | Santa Rosa, California 95403 |
| Northwest Community Hospital | Arlington Heights, Illinois 60005 |
| Lutheran General Cancer Care Center | Park Ridge, Illinois 60068 |
| Methodist Medical Center of Illinois | Peoria, Illinois 61636 |
| Memorial Hospital of South Bend | South Bend, Indiana 46601 |
| Cape Cod Hospital | Hyannis, Massachusetts 02601 |
| CCOP - Montana Cancer Consortium | Billings, Montana 59101 |
| John F. Kennedy Medical Center | Edison, New Jersey 08818 |
| Newark Beth Israel Medical Center | Newark, New Jersey 07112 |
| CCOP - Columbus | Columbus, Ohio 43206 |
| Reading Hospital and Medical Center | Reading, Pennsylvania 19612-6052 |
| Mercy Hospital Cancer Center - Scranton | Scranton, Pennsylvania 18501 |
| CCOP - MainLine Health | Wynnewood, Pennsylvania 19096 |
| CCOP - Greenville | Greenville, South Carolina 29615 |
| University of Texas Medical Branch | Galveston, Texas 77555-1329 |
| Joe Arrington Cancer Research and Treatment Center | Lubbock, Texas 79410-1894 |
| LDS Hospital | Salt Lake City, Utah 84143 |
| University of Wisconsin Comprehensive Cancer Center | Madison, Wisconsin 53792 |
| University of Miami Sylvester Comprehensive Cancer Center | Miami, Florida 33136 |
| CCOP - Northern Indiana CR Consortium | South Bend, Indiana 46601 |
| CCOP - Grand Rapids | Grand Rapids, Michigan 49503 |
| Ellis Fischel Cancer Center at University of Missouri - Columbia | Columbia, Missouri 65203 |
| Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | Lebanon, New Hampshire 03756-0002 |
| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Chapel Hill, North Carolina 27599-7570 |
| MetroHealth's Cancer Care Center at MetroHealth Medical Center | Cleveland, Ohio 44106 |
| Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University | Columbus, Ohio 43210-1240 |
| CCOP - Columbia River Oncology Program | Portland, Oregon 97225 |
| Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia, Pennsylvania 19107 |
| Cancer Research Center of Hawaii | Honolulu, Hawaii 96813 |
| North Shore University Hospital | Manhasset, New York 11030 |
| Cleveland Clinic Taussig Cancer Center | Cleveland, Ohio 44195 |
| USC/Norris Comprehensive Cancer Center and Hospital | Los Angeles, California 90033-0804 |
| CCOP - Virginia Mason Research Center | Seattle, Washington 98101 |
| Utah Valley Regional Medical Center - Provo | Provo, Utah 84604 |
| Peninsula Regional Medical Center | Salisbury, Maryland 21801 |
| MidMichigan Medical Center - Midland | Midland, Michigan 48670 |
| Monmouth Medical Center | Long Branch, New Jersey 07740-6395 |
| Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center | Milwaukee, Wisconsin 53201-2901 |
| University of California Davis Cancer Center | Sacramento, California 95817 |
| Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute | Boston, Massachusetts 02115 |
| University of New Mexico Cancer Research and Treatment Center | Albuquerque, New Mexico 87131 |
| Fletcher Allen Health Care - University Health Center Campus | Burlington, Vermont 05401 |
| Mobile Infirmary Medical Center | Mobile, Alabama 36640-0460 |
| St. Vincent Mercy Medical Center | Toledo, Ohio 43608 |
| Palmetto Health South Carolina Cancer Center | Columbia, South Carolina 29203 |
| Hillman Cancer Center at University of Pittsburgh Cancer Institute | Pittsburgh, Pennsylvania 15236 |
| Great Falls Clinic | Great Falls, Montana 59405 |
| Cancer Research Center at Boston Medical Center | Boston, Massachusetts 02118 |
| Josephine Ford Cancer Center at Henry Ford Hospital | Detroit, Michigan 48202 |
| Cancer Institute at Oregon Health and Science University | Portland, Oregon 97201-3098 |
| Swedish Cancer Institute at Swedish Medical Center - First Hill Campus | Seattle, Washington 98104 |
| Blumenthal Cancer Center at Carolinas Medical Center | Charlotte, North Carolina 28232-2861 |
| McDowell Cancer Center at Akron General Medical Center | Akron, Ohio 44307 |
| Sioux Valley Hospital and University of South Dakota Medical Center | Sioux Falls, South Dakota 57117-5134 |
| M.D. Anderson Cancer Center at University of Texas | Houston, Texas 77030 |
| Central Baptist Hospital | Lexington, Kentucky 40503 |
| Trinity Cancer Care Center | Minot, North Dakota 58701 |
| CCOP - Toledo Community Hospital | Toledo, Ohio 43623-3456 |
| St. Luke's Hospital Cancer Center | Bethlehem, Pennsylvania 18015 |
| Mercy Fitzgerald Hospital | Darby, Pennsylvania 19023 |
| Waukesha Memorial Hospital Regional Cancer Center | Waukesha, Wisconsin 53188 |
| Long Island Jewish Medical Center | New Hyde Park, New York 11040 |
| University of Florida Shands Cancer Center | Gainesville, Florida 32610-0232 |
| Baptist-South Miami Regional Cancer Program | Miami, Florida 33176 |
| St. Luke's Mountain States Tumor Institute - Boise | Boise, Idaho 83712-6297 |
| Spectrum Health Cancer Care - Butterworth Campus | Grand Rapids, Michigan 49503-2560 |
| Breslin Cancer Center at Ingham Regional Medical Center | Lansing, Michigan 48910 |
| Medical University of Ohio Cancer Center | Toledo, Ohio 43614 |
| Legacy Emanuel Hospital and Health Center & Children's Hospital | Portland, Oregon 97227 |
| Naval Medical Center - Portsmouth | Portsmouth, Virginia 23708-2197 |
| St. Vincent Hospital Regional Cancer Center | Green Bay, Wisconsin 54307-3508 |
| Lahey Clinic Medical Center - Burlington | Burlington, Massachusetts 01805 |
| St. Mary's - Duluth Clinic Cancer Center | Duluth, Minnesota 55805 |
| Fox Chase-Temple Cancer Center CCOP Research Base | Philadelphia, Pennsylvania 19111-2442 |
| Saint Peter's University Hospital | New Brunswick, New Jersey 08901-1780 |
| Green Bay Oncology, Limited - Escanaba | Escanaba, Michigan 49431 |
| CCOP - Hematology-Oncology Associates of Central New York | East Syracuse, New York 13057 |
| Mount Nittany Medical Center | State College, Pennsylvania 16803 |
| St. Mary's Hospital Medical Center - Green Bay | Green Bay, Wisconsin 54303 |
| Green Bay Oncology, Limited at St. Mary's Hospital | Green Bay, Wisconsin 54303 |
| Bay Area Cancer Care Center at Bay Area Medical Center | Marinette, Wisconsin 54143 |
| Green Bay Oncology, Limited - Oconto Falls | Oconto Falls, Wisconsin 54154 |
| Green Bay Oncology, Limited - Sturgeon Bay | Sturgeon Bay, Wisconsin 54235 |
| Torrance Memorial Medical Center | Torrance, California 90505 |
| Batte Cancer Center at Northeast Medical Center | Concord, North Carolina 28025 |
| Lacks Cancer Center at Saint Mary's Mercy Medical Center | Grand Rapids, Michigan 49503 |
| Northern Michigan Hospital | Petoskey, Michigan 49770 |
| William Beaumont Hospital - Royal Oak Campus | Royal Oak, Michigan 48073 |
| Munson Medical Center | Traverse City, Michigan 49684 |
| Northern Rockies Radiation Oncology Center | Billings, Montana 59101 |
| Deaconess Billings Clinic - Downtown | Billings, Montana 59101 |
| Fox Chase Virtua Health Cancer Program - Marlton | Marlton, New Jersey 08053 |
| Wayne Memorial Hospital, Incorporated | Goldsboro, North Carolina 27534 |
| Adena Regional Medical Center | Chillicothe, Ohio 54601 |
| Riverside Methodist Hospital Cancer Care | Columbus, Ohio 43214 |
| Grady Memorial Hospital | Delaware, Ohio 43015 |
| Strecker Cancer Center at Marietta Memorial Hospital | Marietta, Ohio 45750 |
| Licking Memorial Cancer Care Program at Licking Memorial Hospital | Newark, Ohio 43055 |
| Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital | Westerville, Ohio 43081 |
| Cottonwood Hospital Medical Center | Murray, Utah 84107 |
| McKay-Dee Hospital Center | Ogden, Utah 84403 |
| Utah Cancer Specialists at UCS Cancer Center | Salt Lake City, Utah 84106 |
| University Cancer Center at University of Washington Medical Center | Seattle, Washington 98195 |
| Group Health Central Hospital | Seattle, Washington 98104 |
| Cancer Care Northwest - Spokane South | Spokane, Washington 99202 |
| Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph | Saint Joseph, Michigan 49085 |
| Lenoir Memorial Cancer Center | Kinston, North Carolina 28503-1678 |
| Zimmer Cancer Center at New Hanover Regional Medical Center | Wilmington, North Carolina 28402-9025 |
| Lombardi Comprehensive Cancer Center at Georgetown University Medical Center | Washington, District of Columbia 20007 |
| CCOP - Nevada Cancer Research Foundation | Las Vegas, Nevada 89109-2306 |
| Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School | New Brunswick, New Jersey 08903 |
| Madigan Army Medical Center - Tacoma | Tacoma, Washington 98431 |
| Brigham and Women's Hospital | Boston, Massachusetts 02115 |
| Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital | Greenville, North Carolina 27858-4354 |
| Robert H. Lurie Comprehensive Cancer Center at Northwestern University | Chicago, Illinois 60611 |
| Paoli Memorial Hospital | Paoli, Pennsylvania 19301-1792 |
| Elkhart General Hospital | Elkhart, Indiana 46515 |
| Maine Medical Center - Bramhall Campus | Portland, Maine 04102 |
| Mount Carmel Health - West Hospital | Columbus, Ohio 43222 |
| Hillcrest Cancer Center at Hillcrest Hospital | Mayfield Heights, Ohio 44124 |
| Rosenfeld Cancer Center at Abington Memorial Hospital | Abington, Pennsylvania 19001 |
| Lakeland Regional Cancer Center at Lakeland Regional Medical Center | Lakeland, Florida 33805 |
| Mount Diablo Regional Cancer Center | Concord, California 94524-4110 |
| North Bay Cancer Center | Fairfield, California 94533 |
| Memorial Medical Center Cancer Services | Modesto, California 95355 |
| John Muir/Mt. Diablo Comprehensive Cancer Center | Walnut Creek, California 94598 |
| St. Joseph Medical Center | Bloomington, Illinois 61701 |
| InterCommunity Cancer Center of Western Illinois | Galesburg, Illinois 61401 |
| BroMenn Regional Medical Center | Normal, Illinois 61761 |
| Community Cancer Center | Normal, Illinois 61761 |
| Cancer Treatment Center at Pekin Hospital | Pekin, Illinois 61554 |
| Oncology Hematology Associates of Central Illinois, PC - Peoria | Peoria, Illinois 61615 |
| OSF St. Francis Medical Center | Peoria, Illinois 61637 |
| Valley Cancer Center | Spring Valley, Illinois 61362 |
| Howard Community Hospital at Howard Regional Health System | Kokomo, Indiana 46904 |
| Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte, Indiana 46350 |
| St. Luke's Hospital | Cedar Rapids, Iowa 52402 |
| Mercy Regional Cancer Center at Mercy Medical Center | Cedar Rapids, Iowa 52403 |
| Stormont-Vail Cancer Center | Topeka, Kansas 66604 |
| St. Francis Comprehensive Cancer Center | Topeka, Kansas 66606 |
| Hickman Cancer Center at Bixby Medical Center | Adrian, Michigan 49221 |
| St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital | Ann Arbor, Michigan 48106-0995 |
| Green Bay Oncology, Limited - Iron Mountain | Iron Mountain, Michigan 49801 |
| Upper Michigan Cancer Center at Marquette General Hospital | Marquette, Michigan 49855 |
| Virginia Piper Cancer Institute at Abbott-Northwestern Hospital | Minneapolis, Minnesota 55407 |
| Hubert H. Humphrey Cancer Center at North Memorial Medical Center | Robbinsdale, Minnesota 55422-2900 |
| Coborn Cancer Center | Saint Cloud, Minnesota 56303 |
| CentraCare Clinic - River Campus | St. Cloud, Minnesota 56303 |
| Park Nicollet Health Services | St. Louis Park, Minnesota 55416 |
| Booker Cancer Center at Riverview Medical Center | Red Bank, New Jersey 07701 |
| Fox Chase Cancer Center at St. Francis Medical Center | Trenton, New Jersey 08629 |
| Cancer Institute of New Jersey at Cooper - Voorhees | Voorhees, New Jersey 08043 |
| Wayne Radiation Oncology | Goldsboro, North Carolina 27534 |
| Blanchard Valley Medical Associates | Findlay, Ohio 45840 |
| Lima Memorial Hospital | Lima, Ohio 45804 |
| Northwest Ohio Oncology Center | Maumee, Ohio 43537 |
| St. Charles Mercy Hospital | Oregon, Ohio 43616 |
| Firelands Regional Medical Center | Sandusky, Ohio 44870 |
| Mercy Medical Center | Springfield, Ohio 45504 |
| Promedica Cancer Center at Flower Hospital | Sylvania, Ohio 43560 |
| Toledo Clinic, Incorporated - Main Clinic | Toledo, Ohio 43623 |
| Legacy Mount Hood Medical Center | Gresham, Oregon 97030 |
| Providence Milwaukie Hospital | Milwaukie, Oregon 97222 |
| Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer Center | Portland, Oregon 97210 |
| Providence Cancer Center at Providence Portland Medical Center | Portland, Oregon 97213-2967 |
| Providence St. Vincent Medical Center | Portland, Oregon 97225 |
| Legacy Meridian Park Hospital | Tualatin, Oregon 97062 |
| Bryn Mawr Hospital | Bryn Mawr, Pennsylvania 19010 |
| St. Mary Regional Cancer Center | Langhorne, Pennsylvania 19047 |
| Lankenau Cancer Center at Lankenau Hospital | Wynnewood, Pennsylvania 19096 |
| Bon Secours St. Francis Health System | Greenville, South Carolina 29601 |
| Doctor's Hospital of Laredo | Laredo, Texas 78041 |
| Dixie Regional Medical Center - East Campus | Saint George, Utah 84770 |
| Southwest Washington Medical Center Cancer Center | Vancouver, Washington 98668 |
| Green Bay Oncology, Limited at St. Vincent Hospital | Green Bay, Wisconsin 54301-3526 |
| Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital | Fairbanks, Alaska 99701 |
| DeCesaris Cancer Institute at Anne Arundel Medical Center | Annapolis, Maryland 21401 |
| St. Francis Hospital | Federal Way, Washington 98003 |
| Cascade Cancer Center at Evergreen Hospital Medical Center | Kirkland, Washington 98034-3013 |
| Providence Holy Cross Cancer Center | Mission Hills, California 91346-9600 |
| Northeast Georgia Medical Center | Gainesville, Georgia 30501 |
| Good Shepherd Hospital | Barrington, Illinois 60010 |
| Creticos Cancer Center at Advocate Illinois Masonic Medical Center | Chicago, Illinois 60657 |
| Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County | Madisonville, Kentucky 42431 |
| Central Maine Medical Center | Lewiston, Maine 04240 |
| Bethke Cancer Center at Emerson Hospital | Concord, Massachusetts 01742 |
| Hudner Oncology Center at Saint Anne's Hospital | Fall River, Massachusetts 02721 |
| Great Lakes Cancer Institute at McLaren Regional Medical Center | Flint, Michigan 48532 |
| West Allis Memorial Hospital | West Allis, Wisconsin 53227 |
| Eastern Connecticut Hematology and Oncology Associates | Norwich, Connecticut 06360 |
| Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler | Savannah, Georgia 31405 |
| Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center | Green Bay, Wisconsin 54311 |
| Methodist Cancer Center at Methodist Hospital - Omaha | Omaha, Nebraska 68114 |
| St. Francis Medical Center | Honolulu, Hawaii 96817 |
| John H. Stroger, Jr. Hospital of Cook County | Chicago, Illinois 60612-9985 |
| Arizona Oncology Services Foundation | Phoenix, Arizona 85013 |
| Saint Joseph's Mercy Cancer Center | Hot Springs, Arkansas 71913 |
| Enloe Cancer Center at Enloe Medical Center | Chico, California 95926 |
| Washington Township Hospital | Fremont, California 94538 |
| Saint Agnes Medical Center | Fresno, California 93720-3397 |
| Cancer Care Consultants Medical Associates at Daniel Freeman Memorial Hospital | Inglewood, California 90301 |
| Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center | Pomona, California 91767 |
| Radiological Associates of Sacramento Medical Group, Incorporated | Sacramento, California 95815 |
| Ruby L. Golleher Cancer Program at Presbyterian Intercommunity Hospital | Whittier, California 90602 |
| St. Vincent's Medical Center | Bridgeport, Connecticut 06606 |
| Hospital of Saint Raphael | New Haven, Connecticut 06511 |
| Leeward Radiation Oncology Center | Ewa Beach, Hawaii 96706 |
| Queen's Cancer Institute at Queen's Medical Center | Honolulu, Hawaii 96813 |
| Hematology Oncology Associates of Eastern Idaho | Idaho Falls, Idaho 83404 |
| Advocate Good Samaritan Hospital | Downers Grove, Illinois 60515 |
| St. John's Cancer Center at St. John's Medical Center | Anderson, Indiana 46016 |
| Regional Cancer Institute at Bloomington Hospital | Bloomington, Indiana 47403 |
| Parkview Regional Cancer Center at Parkview Health | Fort Wayne, Indiana 46805 |
| Cancer Treatment Center for Southern Kentucky | Bowling Green, Kentucky 42101 |
| Greater Baltimore Medical Center | Baltimore, Maryland 21204 |
| MetroWest Medical Center - Framingham Union Hospital | Framingham, Massachusetts 01702 |
| Lowell General Hospital | Lowell, Massachusetts 01854 |
| Community Cancer Care at Milford Regional Medical Center | Milford, Massachusetts 01757 |
| Caritas Norwood Hospital | Norwood, Massachusetts 02062 |
| Immanuel St. Joseph's Clinic | Mankato, Minnesota 56002 |
| Good Samaritan Cancer Center at Good Samaritan Hospital | Kearney, Nebraska 68848-1990 |
| Dartmouth - Hitchcock Concord | Concord, New Hampshire 03301 |
| Seacoast Cancer Center at Wentworth-Douglass Hospital | Dover, New Hampshire 03820 |
| Elliot Regional Cancer Center at Elliot Hospital | Manchester, New Hampshire 03103 |
| Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center | Englewood, New Jersey 07631 |
| AtlantiCare Regional Medical Center | Pomona, New Jersey 08240 |
| Albuquerque Regional Medical Center at Lovelace Sandia Health System | Albuquerque, New Mexico 87102 |
| Long Island College Hospital | Brooklyn, New York 11201 |
| Tucker Center for Cancer Care at Orange Regional Medical Center | Middletown, New York 10940-4199 |
| Pardee Memorial Hospital | Hendersonville, North Carolina 28791 |
| Moore Regional Community Hospital Comprehensive Cancer Center | Pinehurst, North Carolina 28374 |
| Rex Cancer Center at Rex Hospital | Raleigh, North Carolina 27607 |
| Rutherford Hospital | Rutherfordton, North Carolina 28139 |
| Wilmed Radiation Oncology Services | Wilson, North Carolina 27893 |
| Bethesda North Hospital | Cincinnati, Ohio 45242 |
| Cancer Treatment Center at Good Samaritan Hospital | Cincinnati, Ohio 45220 |
| St. Joseph Cancer Center at St. Joseph Health Center | Warren, Ohio 44484 |
| Three Rivers Community Hospital | Grants Pass, Oregon 97527 |
| Providence Medford Medical Center | Medford, Oregon 97504 |
| Dubs Cancer Center at Rogue Valley Medical Center | Medford, Oregon 97504 |
| Easton Regional Cancer Center at Easton Hospital | Easton, Pennsylvania 18042 |
| Mercy Cancer Institute at Mercy Hospital | Pittsburgh, Pennsylvania 15219 |
| York Cancer Center at Wellspan Health | York, Pennsylvania 17403 |
| AnMed Health Cancer Center | Anderson, South Carolina 29621 |
| Gibbs Regional Cancer Center at Spartanburg Regional Medical Center | Spartanburg, South Carolina 29303 |
| Community Cancer Center at Rutland Regional Medical Center | Rutland, Vermont 05701 |
| Martha Jefferson Hospital Cancer Care Center | Charlottesville, Virginia 22901 |
| Theda Care Cancer Institute | Appleton, Wisconsin 54911 |
| Community Memorial Hospital Cancer Care Center | Menomonee Falls, Wisconsin 53051 |
| Columbia St. Mary's Cancer Care Center | Milwaukee, Wisconsin 53211 |
| Regional Cancer Center at Oconomowoc Memorial Hospital | Oconomowoc, Wisconsin 53066 |
